Specifications Table

Product Name – 4-Fluoro-2-methylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – AcroSeal® (moisture-sensitive, high-purity)
Application – Grignard reagent for organic synthesis, C-C bond formation

Product Overview

This 4-fluoro-2-methylphenylmagnesium bromide solution is a specialized Grignard reagent supplied as a 0.5M concentration in anhydrous tetrahydrofuran (THF). The AcroSeal® packaging ensures maximum stability by preventing moisture contamination, which is critical for maintaining the reagent’s reactivity. The fluorinated aromatic structure provides unique reactivity patterns in nucleophilic addition and substitution reactions, making it valuable for synthesizing fluorinated organic compounds. The THF solvent is rigorously dried and stabilized to prevent decomposition, while the sealed format minimizes exposure to atmospheric oxygen and humidity. This reagent is particularly useful in applications requiring precise control over reaction conditions, where moisture or impurities could compromise yields. The solution’s consistency and purity are verified through strict quality control, ensuring reliable performance in laboratory settings. Proper handling and storage under inert conditions are recommended to preserve its reactivity.

FAQs

1. What is the shelf life of this 4-fluoro-2-methylphenylmagnesium bromide solution?

The solution remains stable for 12 months from the date of manufacture when stored unopened at 2-8°C under inert conditions. Once opened, use within 3 months for optimal reactivity.

2. Can this reagent be used with other solvents besides THF?

While formulated in THF for stability, it can be transferred to anhydrous diethyl ether or toluene under inert atmosphere, though reactivity may vary. Avoid protic solvents like alcohols or water.

3. How should I dispose of unused or expired solution?

Neutralize carefully with a dilute acid (e.g., 1M HCl) in a well-ventilated fume hood, then follow local regulations for hazardous chemical disposal. Never discard active Grignard reagents directly.

4. Is this solution compatible with air-sensitive reaction setups?

Yes, the AcroSeal® packaging is designed for air-sensitive applications. For best results, transfer the solution using syringe techniques under nitrogen or argon.

5. What alternatives exist if this specific fluorinated Grignard is unavailable?

Consider 4-fluorophenylmagnesium bromide (non-methylated) or prepare the reagent in-house from 4-fluoro-2-methylbromobenzene and magnesium turnings in THF, though yields may differ.