Specifications Table

Product Name – 4-Methoxyphenylmagnesium bromide, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – AcroSeal® (high-purity, air/moisture-sensitive)
Application – Grignard reagent for organic synthesis, C-C bond formation

Product Overview

4-Methoxyphenylmagnesium bromide is a highly reactive Grignard reagent supplied as a 1M solution in tetrahydrofuran (THF) under the AcroSeal® brand, ensuring superior purity and stability for demanding organic synthesis applications. This organomagnesium compound features a methoxy-substituted phenyl group, which enhances its nucleophilicity and selectivity in carbon-carbon bond-forming reactions. The THF solvent provides optimal solubility and reactivity while maintaining the reagent’s integrity during storage and handling. Designed for air- and moisture-sensitive applications, the AcroSeal® packaging guarantees minimal exposure to atmospheric contaminants, preserving the reagent’s potency until use. The 1M concentration offers a balanced trade-off between reactivity and ease of dosing, making it suitable for both small-scale laboratory experiments and larger preparative syntheses. Its high purity profile minimizes side reactions, ensuring consistent yields and reproducible results in synthetic protocols.

FAQs

1. What is the typical shelf life of 4-Methoxyphenylmagnesium bromide in THF?

The shelf life is approximately 12 months when stored unopened at 2-8°C under inert conditions. Once opened, use within 6 months for optimal reactivity.

2. Is this reagent compatible with glassware, or are special materials required?

Standard borosilicate glassware is compatible, but ensure all equipment is thoroughly dried and flushed with inert gas (N₂/Ar) before use to prevent hydrolysis.

3. Can this be used as a direct substitute for phenylmagnesium bromide in reactions?

While structurally similar, the methoxy substituent alters reactivity and selectivity. Test in small-scale trials to validate performance for your specific application.

4. What precautions are needed for long-term storage of unopened bottles?

Store upright in a cool, dry place (2-8°C) away from ignition sources. Keep the original AcroSeal® packaging intact to maintain the inert atmosphere.

5. How does the AcroSeal® packaging differ from standard reagent bottles?

AcroSeal® features a hermetic seal with a septum cap, allowing syringe extraction without exposing the entire contents to air/moisture, unlike traditional screw-cap bottles.