Specifications Table

Product Name – 4-Methyl-1-naphthylmagnesium bromide, 0.25M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Laboratory Grade
Application – Organic synthesis, Grignard reactions, carbon-carbon bond formation

Product Overview

This 0.25M solution of 4-methyl-1-naphthylmagnesium bromide in tetrahydrofuran (THF) is a highly reactive Grignard reagent designed for demanding organic synthesis applications. The compound is packaged under nitrogen in an AcroSeal® bottle to prevent moisture contamination and ensure long-term stability. The methyl-substituted naphthyl structure provides unique reactivity patterns compared to simpler arylmagnesium halides, making it particularly valuable for constructing complex aromatic systems. The THF solvent is rigorously dried and stabilized to maintain reagent integrity during storage and handling. The solution’s concentration is precisely standardized to 0.25M, allowing for accurate stoichiometric calculations in synthetic procedures. The AcroSeal® packaging features a special septum cap that enables syringe extraction while maintaining an inert atmosphere, reducing the risk of hydrolysis during use. This reagent is particularly suitable for reactions requiring sterically hindered organometallic intermediates or where the naphthyl moiety’s electronic properties are critical for reaction outcomes.

FAQs

1. What precautions should be taken when handling this Grignard reagent?

Always work under an inert atmosphere using standard Schlenk techniques. The reagent is highly moisture-sensitive and pyrophoric in air. Use flame-dried glassware and maintain strict exclusion of water throughout handling and reactions.

2. How does the AcroSeal® packaging improve reagent stability?

The AcroSeal® system combines a nitrogen atmosphere with a specially designed septum that prevents air ingress while allowing syringe access. This dual protection significantly extends shelf life compared to traditional packaging methods.

3. Can this reagent be used for large-scale synthesis?

While the 50mL pack size is ideal for laboratory-scale reactions, the reagent can be scaled up by using multiple bottles. For industrial applications, specialized bulk packaging would be required to maintain the same level of moisture protection.

4. What is the typical storage temperature for this solution?

Store at 2-8°C in the original sealed container. Avoid freezing as this may cause solvent expansion. The reagent should be allowed to reach room temperature before opening to prevent condensation of atmospheric moisture.

5. How does the methyl substitution affect the reagent’s reactivity?

The 4-methyl group increases electron density at the reactive site through inductive effects, typically enhancing nucleophilicity compared to unsubstituted naphthylmagnesium bromide. This can lead to faster reaction rates and improved yields in certain transformations.