Specifications Table

Product Name – 4-n-Propylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Reagent Grade
Application – Grignard reagent for C-C bond formation, organic synthesis

Product Overview

This 0.5M 4-n-Propylphenylmagnesium bromide solution in THF is a highly reactive Grignard reagent designed for precise organic synthesis applications. The AcroSeal® packaging ensures maximum stability by protecting the moisture-sensitive reagent from atmospheric exposure, maintaining its potency until use. The reagent is prepared in anhydrous tetrahydrofuran (THF), a solvent that enhances solubility and reactivity for efficient nucleophilic addition and substitution reactions. Its standardized 0.5M concentration allows for accurate stoichiometric calculations, minimizing experimental variability. The solution is filtered to remove particulate impurities, ensuring consistent performance in laboratory settings. As a reagent-grade product, it meets stringent purity requirements for research applications where trace contaminants could affect reaction outcomes. The propylphenyl group provides unique steric and electronic properties that influence reaction selectivity, making this reagent particularly valuable for specialized synthetic routes.

FAQs

1. What precautions should be taken when handling this Grignard reagent?

This reagent is highly air and moisture sensitive. Always handle under inert atmosphere (nitrogen/argon) using dry glassware and syringes. Avoid skin contact and use in a well-ventilated fume hood.

2. Can this solution be stored for extended periods?

The AcroSeal® packaging provides excellent stability, but for optimal performance, use within 12 months of purchase. Store unopened bottles at 2-8°C in a dry environment.

3. What is the typical titration value for this 0.5M solution?

While the nominal concentration is 0.5M, actual titer may vary slightly. For critical applications, we recommend performing an iodine titration to determine the exact molarity before use.

4. Are there any known incompatibilities with this reagent?

This Grignard reagent reacts violently with water, alcohols, and other protic solvents. It may also react exothermically with carbonyl compounds, so additions should be controlled.

5. How does the propylphenyl substituent affect reactivity compared to simpler Grignard reagents?

The propylphenyl group provides increased steric bulk and altered electronic properties, often resulting in different regioselectivity and reaction rates compared to straight-chain alkyl or phenyl Grignard reagents.