Description
Specifications Table
Product Name – 4-(N,N-Dimethyl)aniline magnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Solution (0.5M in THF)
Grade – Synthesis Grade
Application – Grignard reagent for C-C bond formation, aromatic substitution
Product Overview
This 0.5M solution of 4-(N,N-Dimethyl)aniline magnesium bromide in tetrahydrofuran (THF) is a highly reactive Grignard reagent designed for precision organic synthesis. The dimethylaniline moiety enhances nucleophilicity while maintaining stability in the AcroSeal® packaging system, which prevents moisture contamination and degradation. The reagent is prepared under inert conditions to ensure consistent 98%+ purity, with THF serving as both solvent and reaction medium. Its controlled concentration eliminates the need for titration in most applications, while the sealed format extends shelf life compared to traditional Schlenk flask preparations. The solution remains homogeneous at temperatures between -20°C to 25°C, though prolonged exposure to light may cause gradual decomposition. Compatible with standard glassware and inert atmosphere techniques, this reagent integrates seamlessly into existing synthetic workflows without requiring specialized handling beyond typical Grignard protocols.
FAQs
1. What is the exact molar concentration of this Grignard solution?
The solution is standardized at 0.50 ± 0.02M, with batch-specific certificates of analysis available upon request for precise titration values.
2. Can this reagent be used with protic solvents?
No, the Grignard reagent will decompose rapidly in protic solvents like water, alcohols, or carboxylic acids, releasing dimethylaniline and magnesium salts.
3. How does the AcroSeal® packaging differ from standard septa-sealed bottles?
The AcroSeal® system uses a dual-layer septum with an inert polymer coating that reduces oxygen/moisture ingress by 90% compared to conventional rubber septa.
4. What’s the typical induction period when using this reagent?
Most reactions initiate within 5-15 minutes at room temperature, though electron-deficient substrates may require gentle heating to 40-50°C.
5. Are there any known side reactions with carbonyl compounds?
While primarily forming C-C bonds, over-reaction with aldehydes/ketones can produce tertiary alcohols via addition-elimination pathways under forcing conditions.
