Specifications Table

Product Name – 4-Phenoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – Reagent
Application – Grignard reagent for organic synthesis, aryl coupling reactions

Product Overview

4-Phenoxyphenylmagnesium bromide is a highly reactive Grignard reagent supplied as a 0.5M solution in anhydrous tetrahydrofuran (THF) under the AcroSeal® packaging system, ensuring minimal exposure to moisture and oxygen for prolonged shelf stability. This organomagnesium compound is specifically designed for demanding organic synthesis applications, particularly in the formation of carbon-carbon bonds via aryl-magnesium intermediates. The phenoxy-substituted aromatic structure enhances nucleophilicity while maintaining selectivity in cross-coupling reactions. The THF solvent provides optimal solubility and reactivity, making it compatible with a wide range of electrophilic substrates. AcroSeal® technology guarantees consistent performance by preventing solvent evaporation and atmospheric contamination, which is critical for maintaining the reagent’s potency over time. The reagent is purified to remove trace impurities that could interfere with sensitive reactions, ensuring reproducible results in research and development settings. Its standardized concentration eliminates the need for titration prior to use, saving valuable lab time. The dark amber glass bottle with PTFE-lined cap provides additional protection against light-induced degradation and solvent leakage. This product is particularly valuable for synthesizing complex aromatic compounds where traditional Grignard reagents may lack the necessary reactivity or selectivity.

FAQs

1. What precautions should be taken when handling this Grignard reagent?

Always work under inert atmosphere using Schlenk techniques or glove box. The reagent is highly moisture-sensitive and pyrophoric in air. Use flame-dried glassware and anhydrous solvents to prevent decomposition.

2. Can this solution be diluted with other solvents for specific reactions?

The reagent is optimized for THF, but may be compatible with anhydrous ethers like diethyl ether or 2-methylTHF. Avoid protic solvents or chlorinated solvents which may decompose the Grignard reagent.

3. What’s the typical shelf life when stored properly?

When stored unopened at 2-8°C in the original AcroSeal® packaging, the reagent maintains its specified concentration for at least 12 months from date of manufacture.

4. How does the phenoxy substituent affect reactivity compared to simple phenylmagnesium bromide?

The electron-donating phenoxy group increases nucleophilicity at the ortho/para positions while maintaining stability, enabling selective reactions that aren’t possible with unsubstituted phenyl Grignard reagents.

5. What analytical methods confirm the reagent’s purity and concentration?

Each batch is analyzed via complexometric titration for active magnesium content and GC-MS for solvent purity. Residual moisture is quantified using Karl Fischer titration to ensure <50 ppm water content.