Specifications Table

Product Name – 4-tert-Butylphenylmagnesium bromide, 2M solution in diethyl ether, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid (solution in diethyl ether)
Grade – Laboratory reagent
Application – Grignard reactions, organic synthesis

Product Overview

4-tert-Butylphenylmagnesium bromide is a highly reactive 2M solution in diethyl ether, designed for precision in Grignard reactions and advanced organic synthesis. This AcroSeal®-packaged reagent ensures air and moisture sensitivity is minimized, preserving its potency for consistent experimental results. The tert-butyl phenyl group enhances steric hindrance, making it ideal for selective C-C bond formation in complex molecular architectures. The diethyl ether solvent provides optimal solubility and reactivity, while the sealed packaging prevents degradation from environmental exposure. As a laboratory-grade reagent, it meets stringent purity standards, ensuring reliability in research and development applications. The solution’s concentration and stability are optimized for high-yield syntheses, reducing the need for excessive reagent volumes. Whether used in small-scale experiments or larger preparative workflows, this Grignard reagent delivers reproducible performance, critical for synthesizing pharmaceutical intermediates, fine chemicals, or specialty polymers. Store under inert conditions to maintain integrity, and handle with standard organometallic precautions to ensure safety and efficacy.

FAQs

1. What is the shelf life of 4-tert-Butylphenylmagnesium bromide in diethyl ether?

The shelf life is typically 12 months when stored unopened under inert gas at recommended temperatures. Once opened, use promptly to avoid degradation from moisture or oxygen exposure.

2. Can this reagent be used directly in anhydrous reactions without further purification?

Yes, the AcroSeal® packaging ensures high purity and minimal moisture content, making it suitable for direct use in anhydrous conditions. However, always verify solvent dryness if critical for your protocol.

3. What are the key safety precautions for handling this Grignard reagent?

Handle in a fume hood with inert atmosphere (nitrogen/argon), wear flame-resistant gloves, and avoid contact with water or air. Use compatible glassware and quench excess reagent carefully with isopropanol or saturated ammonium chloride.

4. Is this solution compatible with THF or toluene as co-solvents?

Yes, it can be diluted with anhydrous THF or toluene, but ensure the co-solvent is dry and free of peroxides. Test compatibility in small scales if your reaction is sensitive to solvent polarity changes.

5. How does the tert-butyl group influence reactivity compared to unsubstituted phenylmagnesium bromide?

The tert-butyl substituent increases steric bulk, which can enhance selectivity in nucleophilic additions or reduce side reactions like β-hydride elimination. Reactivity may be slightly lower, but this often improves yield in sterically demanding transformations.