Specifications Table

Product Name – 5-Fluoro-2-methoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Solution
Grade – Reagent
Application – Organic synthesis, Grignard reactions

Product Overview

5-Fluoro-2-methoxyphenylmagnesium bromide is a specialized Grignard reagent supplied as a 0.5M solution in anhydrous THF, ensuring high reactivity and stability for demanding organic synthesis applications. The fluorinated aromatic structure combined with the methoxy substituent enhances selectivity in nucleophilic addition and substitution reactions, making it ideal for constructing complex organic molecules. Packaged in AcroSeal® bottles, this reagent is protected from moisture and oxygen, preserving its potency until use. The THF solvent is rigorously dried and stabilized to prevent decomposition, while the 0.5M concentration provides an optimal balance between reactivity and ease of handling. This reagent is particularly valuable in pharmaceutical and agrochemical research where fluorinated building blocks are required. The airtight packaging eliminates the need for immediate use upon opening, reducing waste and improving laboratory efficiency. Each batch undergoes strict quality control to ensure consistent performance in synthetic protocols.

FAQs

1. What is the shelf life of 5-Fluoro-2-methoxyphenylmagnesium bromide in THF?

The solution remains stable for 12 months when stored unopened at room temperature in its original AcroSeal® packaging. Once opened, use within 3 months for optimal reactivity.

2. Can this reagent be used with other solvents besides THF?

While supplied in THF, the reagent can be transferred to anhydrous diethyl ether or toluene under inert conditions, though reactivity may vary depending on the solvent system.

3. What precautions should be taken when handling this Grignard reagent?

Always handle under nitrogen or argon atmosphere using flame-dried glassware. Avoid exposure to moisture or air to prevent violent decomposition.

4. Is this product compatible with standard Schlenk line techniques?

Yes, the AcroSeal® bottle can be directly connected to Schlenk lines for anaerobic transfer, maintaining reagent purity during dispensing.

5. How does the fluoro-methoxy substitution affect reactivity compared to unsubstituted phenylmagnesium bromide?

The electron-donating methoxy group increases nucleophilicity while the fluorine atom provides steric and electronic modulation, often resulting in higher regioselectivity in aromatic substitutions.