Specifications Table

Product Name – 5-Fluoro-2-methylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal®
Quantity/Pack Size – 50ML
Form – Liquid (THF solution)
Grade – AcroSeal®
Application – Organic synthesis, Grignard reactions

Product Overview

5-Fluoro-2-methylphenylmagnesium bromide is a highly reactive Grignard reagent supplied as a 0.5M solution in tetrahydrofuran (THF) under the AcroSeal® brand, ensuring maximum stability and purity. This organomagnesium compound is specifically designed for demanding organic synthesis applications where fluorinated aromatic intermediates are required. The THF solvent system enhances solubility and reactivity while minimizing side reactions, making it a preferred choice for chemists working on complex molecular constructions. The AcroSeal® packaging technology provides an inert atmosphere, preventing moisture contamination and degradation during storage. This reagent maintains consistent performance across multiple batches, with rigorous quality control ensuring minimal impurities that could affect reaction outcomes. The 0.5M concentration offers an optimal balance between reagent strength and ease of handling, allowing for precise stoichiometric control in synthetic procedures. As a fluorinated Grignard reagent, it enables the introduction of fluorine substituents into target molecules, which is particularly valuable for pharmaceutical and agrochemical research where fluorinated compounds often exhibit enhanced biological activity.

FAQs

1. What is the shelf life of this Grignard reagent in THF solution?

When stored unopened under the recommended conditions, this reagent maintains its specified concentration for at least 12 months from the date of manufacture.

2. Can this solution be used directly in reactions without further purification?

The AcroSeal® packaging ensures high purity, but some applications may require titration to verify exact concentration before use in critical reactions.

3. What precautions should be taken when handling this THF solution?

Handle in a fume hood with proper PPE as THF is highly flammable and the reagent is moisture-sensitive. Use dry syringes or cannulas for transfer.

4. Is this reagent compatible with standard glassware?

Yes, but ensure all glassware is thoroughly dried and inert atmosphere techniques are used to prevent decomposition from moisture.

5. What alternatives exist for similar fluorinated Grignard reagents?

Alternatives include 4-fluoro- or 3-fluorophenylmagnesium bromide solutions, though the 2-methyl substitution in this reagent provides distinct steric and electronic properties.