Description
Specifications Table
| Product Name | 5-Fluoro-2-methylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal® |
|---|---|
| Pack Size | 50 mL |
| Form | Liquid (solution in THF) |
| Grade | AcroSeal® (high-purity, moisture-sensitive) |
| Application | Organic synthesis, Grignard reactions, fluorinated intermediate preparation |
Product Description
When precision matters in your organic synthesis, 5-Fluoro-2-methylphenylmagnesium bromide delivers reliable performance. This 0.5M solution in THF, packaged under the trusted AcroSeal® brand, ensures stability and consistency for demanding laboratory applications. Whether you’re working on pharmaceutical intermediates, agrochemical research, or advanced material synthesis, this Grignard reagent provides the reactivity you need with minimal impurities.
The AcroSeal® packaging system is designed to protect moisture-sensitive compounds, maintaining reagent integrity from the moment it leaves our facility until it reaches your lab. Each batch undergoes rigorous quality control to meet the exacting standards researchers expect from Thermofisher products. The 50 mL pack size offers an ideal balance between sufficient quantity for multiple experiments and minimal waste for smaller-scale projects.
For researchers working with fluorinated aromatic systems, this reagent offers a straightforward path to introducing the 5-fluoro-2-methylphenyl group into your target molecules. The THF solvent system ensures good solubility while maintaining the necessary reactivity for Grignard coupling reactions. Always handle with appropriate safety measures, as this is a highly reactive organometallic compound.
At eqipped, we understand that research timelines are critical. That’s why we’ve streamlined our supply chain to get this and other specialty chemicals to your lab quickly, with proper packaging to maintain product integrity during transit. Our team of technical specialists is also available to answer any questions about handling, storage, or application of this reagent in your specific workflow.
Need a reliable Grignard reagent for your next synthesis? Order 5-Fluoro-2-methylphenylmagnesium bromide today and experience the difference quality makes in your research outcomes.
FAQs
What is the typical reaction time for this Grignard reagent?
Reaction times can vary depending on the electrophile and conditions, but most coupling reactions with aldehydes or ketones typically complete within 1-4 hours at room temperature. For less reactive substrates, longer times or elevated temperatures may be required.
Can this reagent be used for large-scale synthesis?
While the 50 mL pack size is ideal for laboratory-scale work, the same chemistry can be scaled up using appropriate equipment. For bulk requirements, contact eqipped for larger quantity options or custom packaging solutions.
What’s the difference between AcroSeal® and regular packaging?
AcroSeal® packaging uses specialized materials and sealing techniques to provide superior moisture barrier properties compared to standard bottles. This is particularly important for air-sensitive reagents like Grignard solutions, ensuring longer shelf life and more consistent performance.
How should I quench excess reagent after my reaction?
Slowly add saturated ammonium chloride solution or dilute hydrochloric acid while maintaining good stirring. Perform this quenching step in a well-ventilated fume hood, as hydrogen gas may be evolved. Always add the quenching solution to the reaction mixture, never the reverse.
What’s the typical yield for coupling reactions with this reagent?
With proper technique and fresh reagent, yields typically range from 70-90% for standard Grignard additions to carbonyl compounds. Lower yields may indicate moisture contamination or degraded reagent. Always perform a small-scale test reaction when using a new batch.
