Specifications Table

Product Name – ACETONITRILE 99.9% GC-HS

Quantity/Pack Size – 250 ml, 500 ml, 1000 ml

Form – Liquid

Grade – GC-HS (Gas Chromatography – High Sensitivity)

Application – HPLC, LC-MS, UV/Vis spectroscopy, sample preparation, organic synthesis

Product Overview

ACETONITRILE 99.9% GC-HS is a high-purity solvent engineered for demanding analytical applications where precision and consistency are critical. This ultra-refined grade ensures minimal UV absorbance, making it the preferred choice for high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) workflows. Its low water content (<0.005%) and negligible impurity profile eliminate baseline noise, enhancing detector sensitivity and reproducibility in trace analysis. The solvent’s high volatility and miscibility with water and organic compounds further extend its utility in sample extraction, purification, and derivatization protocols. Distilled under stringent conditions, this GC-HS grade acetonitrile undergoes rigorous quality control to meet international pharmacopeia standards, including USP, EP, and JP. Its exceptional transparency in the UV-Vis range (down to 190 nm) ensures accurate peak resolution without solvent interference, while its low viscosity optimizes column efficiency and reduces backpressure in chromatographic systems. The solvent is stabilized to prevent peroxide formation, ensuring long-term stability during storage and repeated use. Packaged in amber glass bottles to prevent photodegradation, it arrives ready for immediate use in research, pharmaceutical, and environmental testing laboratories. For applications requiring absolute purity, this acetonitrile grade delivers unmatched performance, reducing the need for additional filtration or degassing steps.

FAQs

1. What is the difference between GC-HS grade and HPLC grade acetonitrile?

GC-HS grade acetonitrile undergoes additional purification steps to achieve lower impurity levels, particularly for volatile compounds, making it superior for gas chromatography and high-sensitivity applications like LC-MS. HPLC grade is optimized for general liquid chromatography but may contain slightly higher residual UV-absorbing impurities.

2. Can this acetonitrile be used for protein precipitation in mass spectrometry?

Yes, the ultra-low impurity profile and high volatility of this 99.9% GC-HS grade make it highly effective for protein precipitation and peptide extraction in mass spectrometry workflows, minimizing ion suppression and background noise.

3. How should I store acetonitrile to maintain its purity?

Store the unopened bottle in a cool, dry place away from direct sunlight and ignition sources. Once opened, tightly seal the bottle and use within 12 months. For long-term storage, consider transferring to smaller amber glass containers to minimize air exposure.

4. Is this solvent compatible with PTFE or polypropylene labware?

ACETONITRILE 99.9% GC-HS is compatible with most PTFE and polypropylene containers, but prolonged exposure may cause swelling or leaching. For critical applications, use glass or HDPE labware to avoid potential contamination.

5. What alternatives exist if acetonitrile is unavailable for my application?

For HPLC applications, methanol (HPLC grade) can be an alternative, though it has higher UV cutoff and viscosity. For LC-MS, a mixture of methanol/water may replace acetonitrile, but gradient optimization is required due to differing elution properties.