Description
Specifications Table
| Product Name | Acetonitrile with 0.1% Formic Acid for LCMS | 800405 | CDH |
|---|---|
| Pack Size | 1 L |
| Form | Liquid |
| Grade | HPLC/LCMS |
| Application | Liquid chromatography-mass spectrometry (LCMS), HPLC, analytical chemistry |
Product Description
When precision matters in your LCMS or HPLC workflows, the quality of your solvent can make all the difference. Acetonitrile with 0.1% formic acid from eqipped is specifically formulated for high-performance liquid chromatography and mass spectrometry applications. This LCMS-grade solvent ensures minimal background noise, sharp peak resolution, and consistent results, making it a trusted choice for researchers, students, and educators across India.
Formic acid is added at 0.1% to enhance ionization efficiency in mass spectrometry, particularly for electrospray ionization (ESI) techniques. This makes it ideal for proteomics, metabolomics, and small-molecule analysis where sensitivity and accuracy are critical. Whether you’re running routine samples or conducting advanced research, this solvent delivers the reliability you need.
At eqipped, we understand the demands of modern laboratories. That’s why we source solvents that meet stringent quality standards, ensuring batch-to-batch consistency. Our acetonitrile with 0.1% formic acid is filtered through 0.2 µm membranes to remove particulates, reducing column clogging and extending the lifespan of your LCMS instrumentation.
Students working on thesis projects, educators setting up practical demonstrations, and researchers pushing the boundaries of analytical chemistry will find this solvent indispensable. Its low UV cutoff and high purity minimize interference, allowing you to focus on your data rather than troubleshooting solvent-related issues.
Upgrade your LCMS workflow today. Buy Acetonitrile with 0.1% Formic Acid online from eqipped and experience the difference quality makes.
Why This Solvent Stands Out
Not all acetonitrile is created equal. For LCMS applications, even trace impurities can compromise your results. This solvent is manufactured under strict quality control to ensure:
Ultra-low particle content to protect your columns and instrumentation.
Consistent pH stabilization with 0.1% formic acid for reproducible ionization.
Low residual aldehydes and ketones to prevent adduct formation in mass spectrometry.
Compatibility with a wide range of LCMS systems, from Agilent to Waters to Shimadzu.
Whether you’re analyzing pharmaceutical compounds, environmental samples, or biological extracts, this solvent helps you achieve cleaner spectra and more reliable quantitation. It’s also an excellent choice for method development, where solvent purity can significantly impact optimization efforts.
Applications in Research and Education
In academic settings, this solvent is frequently used for:
Teaching chromatography principles in undergraduate and postgraduate laboratories.
Thesis projects involving metabolite profiling or drug analysis.
Quality control experiments in pharmaceutical science programs.
Environmental analysis of pesticides or pollutants.
For professional researchers, it’s a go-to solvent for:
Proteomic studies requiring high-sensitivity peptide detection.
Pharmacokinetic studies tracking drug metabolites.
Food safety testing for contaminants like mycotoxins or veterinary drug residues.
Forensic toxicology applications where trace-level detection is crucial.
Need bulk quantities for your lab? Contact eqipped for customized packaging options tailored to your research needs.
Handling and Storage Recommendations
To maintain the integrity of your solvent:
Store at room temperature (15–25°C) in a tightly sealed container.
Avoid exposure to direct sunlight or heat sources.
Use in a well-ventilated area or under a fume hood.
Always wear appropriate PPE, including nitrile gloves and safety goggles.
For long-term storage, consider using amber bottles to prevent photodegradation. If you notice any discoloration or particulate matter, do not use the solvent, as this may indicate contamination.
Compatibility with Common LCMS Workflows
This solvent is optimized for:
Reversed-phase LCMS separations using C18 columns.
Gradient elution methods with water or aqueous buffers.
Both positive and negative ionization modes in ESI.
High-throughput screening applications.
It pairs well with common mobile phase additives like ammonium acetate or ammonium formate, giving you flexibility in method development. For best results, always use LCMS-grade water and other reagents to match the purity of this solvent.
Troubleshooting Common Issues
If you’re experiencing problems with your LCMS runs, consider these solvent-related factors:
High background noise may indicate contaminated solvent or improper storage.
Poor peak shape could result from particulate matter in the solvent.
Inconsistent retention times might be caused by pH fluctuations if formic acid concentration varies.
Reduced sensitivity may occur if the solvent has absorbed moisture from the air.
Using fresh, high-quality solvent like this acetonitrile with 0.1% formic acid can often resolve these issues. At eqipped, we recommend replacing solvents every 3–6 months for optimal performance, even if unopened.
FAQs
What is the difference between HPLC-grade and LCMS-grade acetonitrile?
LCMS-grade acetonitrile undergoes additional purification steps to remove contaminants that could interfere with mass spectrometry detection. It has stricter specifications for UV absorbance, particle content, and residual impurities compared to standard HPLC-grade solvents.
Can I use this solvent for UPLC applications?
Yes, this acetonitrile with 0.1% formic acid is suitable for UPLC systems. Its low particle content and high purity make it compatible with the high-pressure requirements of ultra-performance liquid chromatography.
How does formic acid improve LCMS performance?
Formic acid enhances ionization efficiency in electrospray ionization by providing protons to analyte molecules. This increases sensitivity, particularly for positive ion mode analysis, and helps stabilize spray formation.
What safety precautions should I take when handling this solvent?
Acetonitrile is flammable and toxic if ingested or inhaled. Always work in a fume hood, wear nitrile gloves, and use safety goggles. Avoid skin contact and ensure proper ventilation in your workspace.
Can I buy this solvent in smaller quantities for educational purposes?
Yes, eqipped offers flexible packaging options. While the standard pack size is 1 L, we can accommodate smaller quantities for academic use. Contact our customer support for customized solutions.
Risk Note
Acetonitrile is a hazardous chemical. It is flammable, toxic if swallowed or inhaled, and may cause skin and eye irritation. Use only in well-ventilated areas with appropriate personal protective equipment. In case of accidental ingestion or exposure, seek immediate medical attention. Keep away from heat sources and open flames. Dispose of according to local regulations for hazardous waste.
