Description
Specifications Table
Product Name – Cyclohexylmethylmagnesium bromide, 0.25M solution in THF, AcroSeal® Quantity/Pack Size – 100ML Form – Liquid solution Grade – AcroSeal® (high-purity, air/moisture-sensitive) Application – Organic synthesis, Grignard reagent for carbon-carbon bond formation
Product Overview
Cyclohexylmethylmagnesium bromide is a 0.25M solution in tetrahydrofuran (THF), supplied under the AcroSeal® brand to ensure maximum purity and stability for critical organic synthesis applications. This Grignard reagent features a cyclohexylmethyl group attached to magnesium bromide, providing unique reactivity for carbon-carbon bond formation in complex molecule construction. The THF solvent enhances solubility and reactivity while maintaining solution stability under inert conditions. As an air- and moisture-sensitive compound, it requires careful handling under nitrogen or argon atmosphere to prevent decomposition. The AcroSeal® packaging system includes a special septum seal that allows for multiple withdrawals while minimizing exposure to atmospheric contaminants. This reagent is particularly valuable for introducing cyclohexylmethyl groups into target molecules with precise stereochemical control. The 0.25M concentration offers an optimal balance between reactivity and ease of handling, making it suitable for both small-scale research and process development applications.
FAQs
1. What precautions should be taken when handling this Grignard reagent?
Always work under an inert atmosphere using standard Schlenk techniques or glove box. Avoid exposure to air or moisture as it reacts violently with water. Use dry glassware and solvents, and store under nitrogen or argon.
2. Can this solution be diluted with additional THF if needed?
Yes, but use freshly distilled, anhydrous THF and maintain inert conditions during dilution. The concentration should be adjusted based on your specific reaction requirements while considering the reagent’s stability at lower concentrations.
3. What’s the typical shelf life of this product when stored properly?
When stored unopened at recommended temperatures (typically 2-8°C) under inert atmosphere, the solution maintains its specified concentration for at least 12 months. Always check for precipitate formation before use.
4. Are there any known incompatible solvents or reagents?
Avoid protic solvents like water, alcohols, or carboxylic acids. Also incompatible with strong oxidizing agents, acids, and most polar aprotic solvents that may contain trace water.
5. How should I dispose of excess reagent or waste?
Slowly quench with isopropanol or a dilute acid solution in a well-ventilated fume hood. Neutralize completely before disposal according to your institution’s chemical waste protocols for organomagnesium compounds.
