Description
Specifications Table
Product Name – Cyclopropylmagnesium bromide, 0.5M solution in 2-MeTHF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution in 2-MeTHF)
Grade – Reagent grade (for synthesis)
Application – Grignard reagent for organic synthesis
Product Overview
Cyclopropylmagnesium bromide, supplied as a 0.5M solution in 2-methyltetrahydrofuran (2-MeTHF), is a highly reactive Grignard reagent designed for precision organic synthesis. The AcroSeal® packaging ensures minimal exposure to moisture and oxygen, preserving the reagent’s integrity for consistent performance in cyclopropylation, coupling, and nucleophilic addition reactions. The 2-MeTHF solvent enhances solubility and reactivity compared to traditional ethers, while the sealed format reduces handling risks associated with pyrophoric organometallics. This solution is stabilized to prevent decomposition, offering researchers a reliable tool for synthesizing cyclopropyl-derived compounds with high stereochemical control. The reagent’s concentration and solvent choice are optimized to balance reactivity with practical usability in inert-atmosphere setups. Compatibility with standard Schlenk techniques makes it suitable for both small-scale and preparative applications where moisture-sensitive intermediates are involved.
FAQs
1. What is the shelf life of cyclopropylmagnesium bromide in 2-MeTHF under AcroSeal® packaging?
The sealed solution remains stable for 12–18 months when stored unopened at 2–8°C, though frequent exposure to air or moisture accelerates degradation.
2. Can this reagent be used directly in reactions without further purification?
The AcroSeal® packaging minimizes impurities, but titration is recommended prior to use, especially for moisture-sensitive applications, as residual solvents may affect stoichiometry.
3. Is 2-MeTHF compatible with standard glassware used for Grignard reactions?
Yes, 2-MeTHF is compatible with borosilicate glass and PTFE-sealed joints, but avoid prolonged contact with rubber stoppers, as the solvent may cause swelling.
4. What alternatives exist if 2-MeTHF is not suitable for my synthesis?
Diethyl ether or THF-based solutions are common alternatives, though they may require additional drying steps and offer different solubility profiles for cyclopropyl intermediates.
5. How should unused solution be disposed of after opening?
Quench excess reagent with isopropanol or saturated ammonium chloride solution under inert atmosphere, then neutralize before disposal according to local hazardous waste regulations.
