Description
Specifications Table
| Product Name | Dde-Lys(Fmoc)-Oh 1 G | 8.54000.0001 | Merck |
|---|---|
| Quantity/Pack Size | 1 G |
| Form | Powder |
| Grade | Research Grade |
| Application | Peptide Synthesis, Bioconjugation |
Product Description
Dde-Lys(Fmoc)-Oh is a specialized amino acid derivative designed for advanced peptide synthesis. This Fmoc-protected lysine features a Dde (1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl) group, enabling orthogonal deprotection strategies in solid-phase peptide synthesis (SPPS). Researchers and chemists rely on this high-purity reagent to introduce lysine residues with controlled side-chain protection, ensuring precise peptide assembly.
The Fmoc group allows for standard base-labile deprotection, while the Dde group can be selectively removed under mild hydrazine conditions. This dual-protection approach is particularly valuable in synthesizing complex peptides, branched structures, or cyclic peptides where selective deprotection is critical. Whether you’re working on therapeutic peptides, protein mimics, or biochemical probes, Dde-Lys(Fmoc)-Oh provides the flexibility needed for sophisticated synthetic routes.
At eqipped, we understand the importance of reliable reagents in research. This Merck product undergoes rigorous quality control to ensure batch-to-batch consistency, making it a trusted choice for academic labs, pharmaceutical R&D, and biotech innovators. The 1g pack size is ideal for small-scale synthesis or pilot studies, offering just the right quantity for experimental work without excess waste.
Need high-purity Dde-Lys(Fmoc)-Oh for your next peptide project? Order today and experience seamless delivery across India.
FAQs
What is the difference between Dde and Boc protection in lysine?
Dde (1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl) is an orthogonal protecting group removed by hydrazine, while Boc (tert-butyloxycarbonyl) is acid-labile. Dde allows for selective deprotection in the presence of Fmoc and other acid-sensitive groups.
Can Dde-Lys(Fmoc)-Oh be used in automated peptide synthesizers?
Yes, it is compatible with standard Fmoc-SPPS protocols. However, ensure your synthesizer’s software accounts for the Dde deprotection step, which typically requires a separate hydrazine treatment module.
What is the typical coupling efficiency of this reagent?
With proper activation (e.g., HATU/HOBt or DIC/Oxyma), coupling efficiencies exceed 99% under standard SPPS conditions. Always monitor via Kaiser test or HPLC for optimal results.
Is this product suitable for therapeutic peptide synthesis?
Absolutely. The high purity and orthogonal protection make it ideal for GMP-compliant synthesis of therapeutic peptides, though additional validation may be required for clinical-grade applications.
How should I dispose of unused Dde-Lys(Fmoc)-Oh?
Follow local regulations for chemical waste disposal. Small quantities can often be incinerated, but consult your institution’s EHS guidelines for specific protocols.
