Description
Specifications Table
Product Name – Di-tert-butyl dicarbonate, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid solution
Grade – Reagent grade
Application – Peptide synthesis, amino protection
Product Overview
Di-tert-butyl dicarbonate (Boc anhydride) in a 1M THF solution offers a convenient and stable reagent for laboratory applications requiring precise protection of amino groups. This AcroSeal®-packaged solution ensures minimal exposure to moisture, maintaining reagent integrity for consistent performance. The reagent-grade purity minimizes side reactions, making it suitable for demanding synthesis protocols. The THF solvent enhances solubility and reactivity, facilitating smooth incorporation into organic synthesis workflows. The sealed packaging prevents degradation from atmospheric moisture, extending shelf life and reducing waste. This solution is particularly valued in peptide chemistry for its efficiency in introducing the Boc protecting group, which is easily removed under mild acidic conditions. The standardized concentration eliminates the need for weighing, improving workflow efficiency and reproducibility in research settings.
FAQs
1. What is the shelf life of this Di-tert-butyl dicarbonate solution?
The solution remains stable for 12 months when stored unopened at room temperature in its original AcroSeal® packaging.
2. Can this solution be used directly without further dilution?
Yes, the 1M concentration is ready for direct use in most standard protection protocols without requiring additional dilution.
3. What precautions should be taken when handling this THF solution?
Work in a fume hood as THF is volatile and flammable. Avoid skin contact and use appropriate PPE including gloves and safety goggles.
4. How should this reagent be stored after opening?
After opening, tightly reseal the container and store under nitrogen if possible to prevent moisture absorption and solvent evaporation.
5. What alternatives exist for Boc protection in peptide synthesis?
Fmoc-Cl or Cbz-Cl can be used as alternatives, though they require different deprotection conditions and may affect synthesis strategy.
