Description
Specifications Table
Product Name – Ethyl chloroformate
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – Synthesis Grade (98%+ purity)
Application – Organic synthesis, acylations, carbamate formation, peptide coupling
Product Overview
Ethyl chloroformate is a highly reactive synthesis-grade reagent widely used in organic chemistry for its ability to introduce ethyl carbamate groups through acylation reactions. This colorless to pale yellow liquid possesses a sharp, pungent odor characteristic of chloroformates and boasts a minimum purity of 98%, ensuring reliable results in sensitive applications. Its molecular structure (C3H5ClO2) enables efficient nucleophilic substitution reactions, making it particularly valuable for peptide synthesis and protecting group strategies. The reagent demonstrates excellent solubility in common organic solvents like dichloromethane, THF, and acetone while remaining moisture-sensitive, necessitating proper handling under inert conditions. With a boiling point of 93-95°C and density of 1.14 g/mL, ethyl chloroformate offers predictable behavior in controlled laboratory environments. Its reactivity profile makes it suitable for both small-scale research and larger preparative chemistry applications when proper safety protocols are followed.
FAQs
1. What is the typical shelf life of ethyl chloroformate when stored properly?
When stored in a tightly sealed container under cool, dry conditions away from moisture and heat sources, ethyl chloroformate maintains its specified purity for 12-18 months from the date of manufacture. Always verify the expiration date on the label before use.
2. Can this reagent be used directly without purification for standard organic synthesis?
The 98%+ synthesis grade quality is suitable for most laboratory applications without additional purification. However, for highly sensitive reactions or analytical applications, simple distillation under reduced pressure may be recommended to achieve higher purity levels.
3. What safety precautions should be taken when handling ethyl chloroformate?
Always handle in a well-ventilated fume hood wearing appropriate PPE including chemical-resistant gloves, safety goggles, and lab coat. The reagent is highly corrosive and reacts violently with water, releasing toxic gases. Never use glass containers with ground glass joints as the reagent can fuse them.
4. How does ethyl chloroformate compare to other chloroformate reagents in terms of reactivity?
Ethyl chloroformate offers moderate reactivity among alkyl chloroformates, being more reactive than methyl chloroformate but less so than isobutyl chloroformate. This balanced reactivity profile makes it particularly useful for selective acylations where milder conditions are desired.
5. What is the recommended disposal method for unused or expired ethyl chloroformate?
Unused reagent should be carefully neutralized by slow addition to a cold, dilute sodium hydroxide solution (10% w/v) in a fume hood, followed by proper chemical waste disposal according to local environmental regulations. Never dispose of untreated chloroformate in regular waste streams.
