Description
Specifications Table
| Product Name | Fmoc-1-Methyl-L-Histidine |
|---|---|
| Quantity/Pack Size | 1 G |
| Form | Solid |
| Grade | Research Grade |
| Application | Peptide Synthesis, Biochemical Research |
Product Description
Fmoc-1-Methyl-L-Histidine is a specialized amino acid derivative widely used in peptide synthesis and biochemical research. The Fmoc (9-fluorenylmethoxycarbonyl) protecting group ensures compatibility with solid-phase peptide synthesis (SPPS), while the methyl modification on the histidine side chain introduces unique structural and functional properties to synthesized peptides.
This high-purity compound is essential for researchers working on protein engineering, enzyme studies, or therapeutic peptide development. The 1g pack size provides sufficient quantity for multiple synthesis cycles, making it a cost-effective choice for labs and academic institutions.
When you buy Fmoc-1-Methyl-L-Histidine from eqipped, you get Merck’s reliable quality with the convenience of online ordering. Our platform ensures authentic products with proper documentation, so you can focus on your research without supply chain worries.
Key Applications
Peptide synthesis often requires modified amino acids to achieve specific biological activities. Fmoc-1-Methyl-L-Histidine serves critical roles in:
1. Therapeutic Peptide Development: The methylated histidine residue can enhance peptide stability and binding affinity in drug candidates.
2. Enzyme Substrate Studies: Researchers use it to probe enzyme specificity and catalytic mechanisms involving histidine residues.
3. Protein Mimicry: Incorporating this derivative helps create peptides that mimic natural protein structures with altered properties.
4. Structural Biology: The modification aids in crystallography and NMR studies by providing distinct chemical shifts.
For laboratories looking to buy FMOC-1-methyl-L-histidine in India, eqipped offers a seamless purchasing experience with technical support for your specific applications.
Handling and Storage Recommendations
To maintain the integrity of this sensitive compound:
• Store at -20°C in a desiccated environment away from light
• Avoid repeated freeze-thaw cycles
• Use in a fume hood when handling powders
• Keep containers tightly sealed when not in use
Proper storage ensures the Fmoc protecting group remains intact for reliable synthesis results.
Why This Product Stands Out
Merck’s Fmoc-1-Methyl-L-Histidine offers several advantages that make it the preferred choice among researchers:
The Fmoc protection strategy allows for orthogonal deprotection during peptide synthesis, giving researchers precise control over the synthesis process. The methyl modification on the histidine imidazole ring provides unique electronic and steric properties that aren’t achievable with standard histidine derivatives.
When you order from eqipped, you benefit from our direct sourcing from Merck, ensuring you receive the exact product specified in your research protocols. Our quality assurance process verifies each batch’s purity and identity before shipment.
Compatibility with Synthesis Protocols
This derivative integrates seamlessly with standard Fmoc chemistry protocols:
• Compatible with common coupling reagents like HATU, HBTU, and DIC
• Works well with both manual and automated peptide synthesizers
• The methyl modification doesn’t interfere with standard deprotection conditions
Researchers can incorporate this building block into existing synthesis workflows without needing to develop new protocols.
Safety Considerations
While Fmoc-1-Methyl-L-Histidine is generally safe when handled properly, we recommend:
• Wearing appropriate PPE (gloves, lab coat, safety goggles)
• Working in a well-ventilated area or fume hood
• Following standard laboratory safety procedures for chemical handling
Always refer to the Safety Data Sheet (SDS) for complete handling instructions and emergency measures.
Ordering Information
For researchers looking to buy FMOC-1-methyl-L-histidine online, eqipped provides a straightforward ordering process with multiple payment options and fast delivery across India. Our customer support team can assist with technical questions about product applications or ordering.
Need Fmoc-1-Methyl-L-Histidine for your next synthesis project? Order now and get authentic Merck quality delivered to your lab.
FAQs
What is the purity of this Fmoc-1-Methyl-L-Histidine?
This product meets Merck’s high purity standards, typically >95% as determined by HPLC. Exact purity specifications are provided with each batch’s Certificate of Analysis.
Can I use this for therapeutic peptide production?
While suitable for research and development, this product is not intended for clinical or therapeutic use. Always verify regulatory compliance for your specific application.
What’s the typical shelf life of this product?
When stored properly at -20°C, the product maintains stability for at least 24 months from the date of manufacture.
Do you provide bulk quantities of this product?
For larger research projects, eqipped can arrange bulk orders. Contact our sales team with your requirements for customized solutions.
What coupling reagents work best with this derivative?
Standard Fmoc chemistry coupling reagents like HATU, HBTU, and DIC/Oxyma work effectively. The choice depends on your specific synthesis conditions and peptide sequence.
