Description
Specifications Table
| Product Name | Fmoc-D-His(Trt)-Oh 5 G | 8.52161.0005 | Merck |
|---|---|
| Quantity/Pack Size | 5 GM |
| Form | Powder |
| Grade | Peptide Synthesis Grade |
| Application | Solid-phase peptide synthesis, biochemical research |
Product Description
Fmoc-D-His(Trt)-Oh is a high-quality protected histidine derivative essential for peptide synthesis. This compound features the Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amino terminus and a Trt (trityl) group protecting the imidazole side chain of histidine. The D-configuration makes it particularly useful for synthesizing peptides with specific structural requirements.
Researchers and students working in biochemical laboratories will find this product invaluable for solid-phase peptide synthesis. The Fmoc protection strategy is widely preferred in modern peptide chemistry due to its mild deprotection conditions and compatibility with various coupling reagents. The Trt group ensures the histidine side chain remains protected during synthesis, preventing unwanted side reactions.
When you buy Fmoc-D-His(Trt)-Oh online from eqipped, you’re getting a product that meets the highest standards of purity and consistency. Each batch undergoes rigorous quality control to ensure reliable performance in your experiments. Whether you’re working on therapeutic peptides, enzyme substrates, or structural studies, this compound provides the foundation for successful synthesis.
Looking for reliable FMOC-D-Histidine-OH suppliers in India? eqipped offers authentic Merck products with fast delivery.
The 5g pack size is ideal for both small-scale research projects and larger synthesis requirements. For laboratories that frequently work with peptide synthesis, maintaining a stock of this compound ensures you’re always prepared for your next experiment. The powder form allows for easy weighing and dissolution in appropriate solvents.
When handling this compound, it’s important to follow standard laboratory safety protocols. While not classified as highly hazardous, proper personal protective equipment should be used, and the compound should be stored in a cool, dry place away from moisture and direct light.
FAQs
What is the difference between Fmoc-D-His(Trt)-Oh and regular histidine?
Fmoc-D-His(Trt)-Oh is a protected derivative of D-histidine with Fmoc on the amino group and Trt on the imidazole side chain. This protection prevents unwanted reactions during peptide synthesis, unlike unprotected histidine which would react at multiple sites.
Can I use this compound for Fmoc solid-phase peptide synthesis?
Yes, this compound is specifically designed for Fmoc solid-phase peptide synthesis. The Fmoc group is base-labile and can be easily removed with piperidine, while the Trt group protects the histidine side chain during synthesis.
What solvents work best for dissolving Fmoc-D-His(Trt)-Oh?
The compound is typically soluble in polar aprotic solvents like DMF (dimethylformamide), dichloromethane, and DMSO (dimethyl sulfoxide). These are commonly used in peptide synthesis protocols.
How should I store Fmoc-D-His(Trt)-Oh for long-term use?
For long-term storage, keep the compound at -20°C in a tightly sealed container with desiccant. This prevents moisture absorption and degradation of the protecting groups.
Is this product suitable for therapeutic peptide production?
While this compound is of high purity suitable for research, any use in therapeutic applications would require additional quality control and regulatory compliance measures beyond standard research grade materials.
