Description
Specifications Table
| Product Name | Fmoc-Gln(Trt)-Ser(Psime,Mepro)-Oh | 8.52190.0025 | Merck |
|---|---|
| Quantity/Pack Size | 25 G |
| Form | Solid |
| Grade | Peptide Synthesis Grade |
| Application | Solid-Phase Peptide Synthesis (SPPS) |
Product Description
Fmoc-Gln(Trt)-Ser(Psime,Mepro)-Oh is a specialized amino acid derivative designed for high-efficiency peptide synthesis. This compound features Fmoc protection on the N-terminus, Trt (trityl) protection on the glutamine side chain, and a pseudoproline (Psime,Mepro) modification on serine to enhance solubility and reduce aggregation during synthesis.
Peptide chemists and researchers rely on this reagent for its ability to improve coupling efficiency and minimize side reactions. The pseudoproline modification is particularly valuable in synthesizing difficult sequences, as it disrupts secondary structures that can hinder synthesis.
Whether you’re working on therapeutic peptides, biochemical studies, or custom peptide projects, this Merck product ensures consistent results. eqipped provides this high-purity reagent with proper documentation and fast shipping across India.
Need reliable peptide synthesis reagents? Buy Fmoc-Gln(Trt)-Ser(Psime,Mepro)-Oh online today for seamless SPPS workflows.
Applications in Peptide Synthesis
This compound is specifically engineered for:
1. Solid-phase peptide synthesis (SPPS) of complex sequences
2. Synthesis of peptides with glutamine and serine residues
3. Reduction of aggregation in difficult peptide sequences
4. Improved coupling efficiency in automated synthesizers
The pseudoproline modification makes it particularly useful for synthesizing peptides that tend to form β-sheets or other problematic secondary structures during elongation.
Handling and Storage
Store this compound at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles. For best results, use within the recommended shelf life period as indicated on the certificate of analysis.
Always handle in a well-ventilated fume hood using appropriate personal protective equipment (PPE). This product is for research use only and not intended for human consumption.
Why Researchers Choose This Product
Peptide chemists prefer this Merck product because of its:
Consistent high purity (typically >95% by HPLC)
Reliable batch-to-batch performance
Documented quality control data
Compatibility with standard Fmoc chemistry protocols
eqipped ensures you receive authentic Merck products with proper cold chain shipping when required.
FAQs
What is the purpose of the pseudoproline modification in this compound?
The pseudoproline (Psime,Mepro) modification on serine improves solubility and reduces aggregation during peptide synthesis, making it easier to synthesize difficult sequences.
Can this be used in automated peptide synthesizers?
Yes, this compound is fully compatible with standard Fmoc chemistry protocols used in automated synthesizers.
What is the typical coupling time for this amino acid derivative?
Standard coupling times of 30-60 minutes are typically sufficient, though optimization may be needed for specific sequences.
Is this product suitable for therapeutic peptide production?
While this is a high-quality research-grade reagent, additional validation would be required for GMP-compliant therapeutic production.
How should I store this product after opening?
After opening, store in a desiccator at -20°C and use within 6 months for best results.
