Description
Specifications Table
| Product Name | Fmoc-Lys(Boc)-Thr(ψMe,MePro)-OH | 8.52191.0025 | Merck |
|---|---|
| Pack Size | 25 G |
| Form | Solid |
| Grade | Peptide Synthesis Grade |
| Application | Solid-Phase Peptide Synthesis (SPPS), Proteomics Research |
Product Description
Fmoc-Lys(Boc)-Thr(ψMe,MePro)-OH is a specialized amino acid derivative designed for high-efficiency peptide synthesis. The Fmoc (9-fluorenylmethoxycarbonyl) protecting group ensures compatibility with standard SPPS protocols, while the Boc (tert-butoxycarbonyl) protection on lysine and the pseudoproline (ψMe,MePro) modification on threonine enhance solubility and reduce aggregation during synthesis.
This reagent is particularly valuable for synthesizing complex peptides with challenging sequences, where traditional methods may fail due to secondary structure formation. Researchers in biochemistry, pharmaceutical development, and proteomics rely on this compound for its reliability and consistency in yielding high-purity peptides.
At eqipped, we source this product directly from Merck, ensuring authenticity and batch-to-batch consistency. Whether you’re a student working on a thesis or a seasoned researcher scaling up peptide production, this reagent is a trusted choice for demanding applications.
Why This Reagent Stands Out
The pseudoproline modification in Fmoc-Lys(Boc)-Thr(ψMe,MePro)-OH is a game-changer for peptide chemists. Unlike standard threonine derivatives, this variant minimizes chain termination and improves coupling efficiency, even in difficult sequences. The Boc protection on lysine allows for orthogonal deprotection strategies, giving you greater control over your synthesis workflow.
For laboratories in India looking to buy FMOC-Lys(Boc)-Thr(ψMe,MePro)-OH online, eqipped offers competitive pricing, secure packaging, and fast shipping. Our platform is designed to simplify procurement for academic and industrial researchers alike.
Applications in Research
This reagent is widely used in:
- Therapeutic peptide development (e.g., hormone analogs, antimicrobial peptides)
- Protein-protein interaction studies
- Epitope mapping and vaccine research
- Structural biology and NMR studies
Its versatility makes it a staple in labs focusing on drug discovery, molecular biology, and synthetic chemistry.
Storage and Handling
Store at -20°C in a desiccated environment to maintain stability. Avoid repeated freeze-thaw cycles. For best results, use within 12 months of purchase. Always handle in a fume hood with proper ventilation.
Need bulk quantities or custom packaging? Contact eqipped’s support team for tailored solutions.
FAQs
What is the shelf life of Fmoc-Lys(Boc)-Thr(ψMe,MePro)-OH?
When stored at -20°C under desiccated conditions, this reagent remains stable for up to 12 months. Always check the certificate of analysis for batch-specific data.
Can this reagent be used in automated peptide synthesizers?
Yes, it is fully compatible with most automated SPPS systems, including those from CEM, Gyros, and Biotage. The pseudoproline modification often improves synthesis outcomes in automated workflows.
Is this product available in smaller pack sizes?
Currently, eqipped offers this reagent in a 25g pack size. For smaller quantities, consider splitting the pack under inert conditions or contact us for custom requests.
What safety precautions should I take when handling this chemical?
Wear nitrile gloves, safety goggles, and a lab coat. Work in a fume hood to avoid inhalation. In case of skin contact, wash immediately with soap and water. Refer to the SDS for detailed safety information.
How does the pseudoproline modification improve peptide synthesis?
The ψMe,MePro group disrupts secondary structure formation in the growing peptide chain, reducing aggregation and improving solubility. This leads to higher coupling efficiencies and purer final products, especially for long or hydrophobic sequences.
