Description
Specifications Table
| Product Name | Fmoc-N-Me-Tyr(Tbu)-OH |
|---|---|
| Pack Size | 1G |
| Form | Powder |
| Grade | Peptide Synthesis Grade |
| Application | Solid-phase peptide synthesis, Fmoc chemistry |
Product Description
Fmoc-N-Me-Tyr(Tbu)-OH is a premium-grade protected tyrosine derivative widely used in peptide synthesis. This compound features an N-methylated tyrosine with tert-butyl protection on the phenolic hydroxyl group, ensuring stability during Fmoc-based solid-phase synthesis. Researchers and lab professionals rely on this reagent for its high purity and consistent performance in building complex peptide sequences.
The Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for orthogonal deprotection strategies, making it a preferred choice in automated peptide synthesizers. The tert-butyl (Tbu) protection on the tyrosine side chain prevents unwanted side reactions, ensuring clean coupling steps. Whether you’re working on therapeutic peptides, biochemical assays, or structural biology studies, this reagent delivers reliable results.
At eqipped, we source this product directly from Merck, guaranteeing authenticity and batch-to-batch consistency. Each 1G pack is carefully handled to maintain integrity during storage and shipping. For labs prioritizing precision in peptide synthesis, this compound is an essential addition to your inventory.
Need high-purity peptide synthesis reagents? Buy Fmoc-N-Me-Tyr(Tbu)-OH online today for seamless research workflows.
Key Applications
This compound is specifically designed for:
- Solid-phase peptide synthesis using Fmoc chemistry
- Synthesis of tyrosine-containing peptides with N-methylation
- Preparation of modified peptides for therapeutic research
- Biochemical studies requiring protected amino acid derivatives
Storage and Handling
To maintain optimal performance, store Fmoc-N-Me-Tyr(Tbu)-OH at -20°C in a desiccated environment. Avoid exposure to moisture and light, as these can compromise the compound’s stability. Always use dry solvents and inert atmosphere conditions when handling to prevent premature deprotection.
For long-term storage, divide the contents into smaller aliquots to minimize freeze-thaw cycles. This practice helps preserve the reagent’s reactivity over extended periods, ensuring consistent results in your synthesis protocols.
Safety Considerations
While this compound is generally stable under recommended conditions, standard laboratory safety practices should be followed. Wear appropriate personal protective equipment (PPE) including gloves and safety goggles when handling. Work in a well-ventilated area or under a fume hood to avoid inhalation of fine particles.
In case of skin contact, wash thoroughly with soap and water. For eye exposure, rinse immediately with plenty of water and seek medical attention if irritation persists. Refer to the Safety Data Sheet (SDS) for comprehensive handling and disposal guidelines.
FAQs
What is the purity level of Fmoc-N-Me-Tyr(Tbu)-OH from eqipped?
Our Fmoc-N-Me-Tyr(Tbu)-OH maintains a minimum purity of 99%, verified through HPLC analysis. This high purity ensures reliable performance in peptide synthesis applications.
Can this compound be used in automated peptide synthesizers?
Yes, this reagent is fully compatible with standard Fmoc-based automated peptide synthesizers. Its solubility and coupling efficiency make it ideal for machine-assisted synthesis protocols.
What solvents work best for dissolving Fmoc-N-Me-Tyr(Tbu)-OH?
Common solvents like DMF (dimethylformamide) or NMP (N-methyl-2-pyrrolidone) are typically used. For optimal results, we recommend using freshly opened, anhydrous solvents to prevent moisture-related side reactions.
How does the N-methylation affect peptide properties?
The N-methylation on tyrosine can influence peptide conformation and biological activity. It often enhances metabolic stability and can alter binding affinities in biological systems, making it valuable for drug development research.
What’s the typical coupling time for this amino acid derivative?
Under standard Fmoc synthesis conditions, coupling times typically range from 30 to 60 minutes. However, optimal timing may vary based on your specific synthesis protocol and equipment.
