Description
Specifications Table
Product Name – Isobutyryl chloride
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – Synthesis Grade
Application – Organic synthesis, acylations, pharmaceutical intermediates
Product Overview
Isobutyryl chloride is a highly reactive acyl chloride used extensively in organic synthesis for introducing the isobutyryl functional group. This colorless to pale yellow liquid boasts a purity of 98%+, ensuring reliable results in Friedel-Crafts acylations, esterifications, and amide formations. Its branched alkyl structure provides unique steric properties compared to linear acyl chlorides, making it valuable for synthesizing specialty chemicals and pharmaceutical intermediates. The reagent is moisture-sensitive and must be handled under anhydrous conditions to prevent hydrolysis. Its boiling point of 92-95°C allows for easy purification via distillation when required. The compound’s reactivity with alcohols, amines, and aromatic systems makes it a versatile building block in multi-step organic transformations. Proper storage in tightly sealed containers under inert gas extends shelf life and maintains reactivity. Always use in a well-ventilated fume hood with appropriate PPE due to its corrosive nature and pungent odor.
FAQs
1. What is the typical shelf life of isobutyryl chloride when stored properly?
When stored in a cool, dry place under nitrogen in tightly sealed original containers, isobutyryl chloride maintains its specified purity for 12-18 months from the date of manufacture.
2. Can this reagent be used directly in aqueous reaction systems?
Isobutyryl chloride hydrolyzes rapidly in water, so it should only be used in strictly anhydrous solvent systems for intended reactions.
3. What are the key safety precautions when handling this chemical?
Always wear nitrile gloves, safety goggles, and work in a fume hood. Avoid inhalation of vapors and skin contact as it causes severe burns. Have sodium bicarbonate solution ready for spills.
4. How does isobutyryl chloride compare to pivaloyl chloride in reactivity?
Isobutyryl chloride is generally more reactive than pivaloyl chloride due to less steric hindrance around the carbonyl carbon, making it more suitable for challenging acylation reactions.
5. What’s the recommended method for verifying the purity of this reagent?
The purity can be confirmed via gas chromatography or by determining the hydrolysis value through titration with standardized sodium hydroxide solution.
