Description
Specifications Table
Product Name – Lithium bis(trimethylsilyl)amide, 1M solution in THF, AcroSeal® Quantity/Pack Size – 100ML, 800ML Form – Liquid (THF solution) Grade – AcroSeal® (high-purity, moisture-sensitive) Application – Strong non-nucleophilic base for organic synthesis
Product Overview
Lithium bis(trimethylsilyl)amide (LiHMDS) is a powerful, non-nucleophilic superbase widely used in organic synthesis for deprotonation reactions. This 1M solution in THF offers enhanced solubility and reactivity, making it ideal for sensitive applications where moisture or air exposure must be minimized. The AcroSeal® packaging ensures long-term stability by preventing contamination, while the THF solvent provides compatibility with a broad range of substrates. Its high basicity (pKa ~26) enables efficient enolate formation, alkylation, and condensation reactions without competing nucleophilic side reactions. The solution is stored under inert conditions to maintain purity, and its clear, colorless appearance indicates minimal impurities. Researchers rely on this reagent for reproducible results in demanding synthetic routes, particularly in pharmaceutical and fine chemical development. Proper handling under dry, inert atmospheres is recommended to preserve its potency.
FAQs
1. What is the shelf life of Lithium Bis(trimethylsilyl)amide 1M in THF?
The solution remains stable for 12–18 months when stored unopened under nitrogen at 2–8°C. Avoid prolonged exposure to air or moisture.
2. Can this solution replace LDA (lithium diisopropylamide) in reactions?
Yes, LiHMDS is often preferred over LDA due to its higher solubility in THF and reduced nucleophilicity, minimizing side reactions.
3. Is this product compatible with glassware or requires special containers?
It is compatible with standard borosilicate glassware, but ensure all equipment is dry and inert-gas purged before use.
4. What precautions are needed for handling this solution?
Use in a fume hood with nitrogen atmosphere. Wear gloves, goggles, and lab coats to avoid skin or eye contact with the corrosive solution.
5. Are there lower-concentration alternatives available for less demanding applications?
Lower concentrations (e.g., 0.5M) may be sourced separately, but this 1M solution is optimized for high-efficiency reactions.
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