Description
Specifications Table
Product Name – Lithium borohydride, 4M (10 wt.%) solution in THF, AcroSeal® Quantity/Pack Size – 100ML, 800ML Form – Liquid (solution in THF) Grade – Laboratory reagent grade Application – Reducing agent for aldehydes, ketones, esters, and carboxylic acids
Product Overview
Lithium borohydride (LiBH₄) in tetrahydrofuran (THF) is a highly efficient reducing agent designed for selective organic transformations. This 4M (10 wt.%) solution leverages the stability of AcroSeal® packaging to minimize moisture exposure, ensuring consistent performance in sensitive reactions. The reagent exhibits superior reactivity compared to sodium borohydride, enabling reductions at lower temperatures and with enhanced chemoselectivity. The THF solvent enhances solubility and reactivity, making it particularly effective for reducing aldehydes, ketones, esters, and carboxylic acids without affecting olefinic or aromatic functionalities. Its controlled reactivity profile reduces side reactions, making it a preferred choice for complex syntheses requiring precision. The solution is compatible with standard glassware and can be handled under inert conditions for optimal results. For researchers prioritizing reproducibility, this reagent delivers reliable stoichiometric control, minimizing waste and improving yield efficiency in multi-step syntheses.
FAQs
1. What is the shelf life of lithium borohydride in THF when stored properly?
When stored under inert gas at 2–8°C in its original AcroSeal® packaging, the solution remains stable for up to 12 months. Avoid prolonged exposure to air or moisture, as it accelerates decomposition.
2. Can this solution be used directly for reductions, or does it require activation?
The 4M solution is ready for immediate use in most reductions without additional activation. However, for sluggish substrates, adding a catalytic amount of methanol or ethanol may enhance reaction rates.
3. What precautions should be taken when handling this reagent?
Lithium borohydride is highly reactive with water and protic solvents, releasing hydrogen gas. Always handle under a fume hood using dry syringes or cannula techniques. Wear nitrile gloves and safety goggles to prevent contact with skin or eyes.
4. Is this solution compatible with common laboratory solvents like dichloromethane or ether?
While THF is the primary solvent, the solution can be diluted with anhydrous ether or toluene. Avoid halogenated solvents like dichloromethane, as they may lead to side reactions or reduced efficacy.
5. How does this compare to sodium borohydride in terms of reducing power?
Lithium borohydride is significantly more reactive than sodium borohydride, enabling reductions at lower temperatures and shorter reaction times. It is particularly effective for sterically hindered or less reactive carbonyl compounds where NaBH₄ fails.
