Description
Specifications Table
Product Name – Lithium isopropoxide, 3M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – Reagent grade (99%+ assay)
Application – Strong base for deprotonation, enolate formation, transmetalation
Product Overview
Lithium isopropoxide 3M solution in THF is a highly reactive, moisture-sensitive organolithium reagent supplied in AcroSeal® packaging to maintain purity and prevent degradation. This reagent-grade solution offers a 99%+ assay, ensuring consistent performance in demanding synthetic applications. The tetrahydrofuran (THF) solvent system provides excellent solubility for lithium alkoxides while maintaining stability during storage. The 3M concentration delivers optimal reactivity for deprotonation reactions, enolate formations, and transmetalation processes without requiring additional dilution. The AcroSeal® packaging features a septum cap for convenient syringe extraction, minimizing exposure to atmospheric moisture and oxygen. This solution is particularly valued for its ability to generate lithium enolates under mild conditions, making it a preferred choice over traditional bases like LDA in certain applications. The reagent’s high nucleophilicity and basicity enable efficient C-C bond formations and functional group transformations in complex organic synthesis.
FAQs
1. What precautions should be taken when handling lithium isopropoxide 3M in THF?
Always work under inert atmosphere using dry nitrogen or argon. Use oven-dried glassware and moisture-free solvents. The solution is highly flammable and reacts violently with water.
2. Can this solution be used as a direct replacement for LDA in reactions?
While similar in basicity, lithium isopropoxide often provides better selectivity in certain enolate formations. Reaction conditions may need optimization as the steric profile differs from LDA.
3. How should the unopened bottles be stored for maximum shelf life?
Store at 2-8°C in the original AcroSeal® packaging, away from moisture and ignition sources. The septum cap should remain intact until use to prevent solvent evaporation.
4. What is the typical moisture content in this AcroSeal® packaged solution?
The packaging maintains moisture levels below 50 ppm when unopened. Each batch includes a certificate of analysis with exact moisture content specifications.
5. Are there any known incompatibilities with common laboratory materials?
The solution reacts with glass at elevated temperatures. Use PTFE-lined caps and avoid prolonged contact with rubber septa, which may degrade in THF solutions.
