Description
Specifications Table
Product Name – Methyl isobutyl ketone (MIBK) USP
Quantity/Pack Size – 100 ml
Form – Liquid
Grade – USP
Application – Solvent, extraction, synthesis
Product Overview
Methyl Isobutyl Ketone (MIBK) USP is a high-purity solvent widely recognized for its versatility in laboratory applications. This colorless liquid exhibits a characteristic ketone odor and is highly effective in dissolving a broad range of organic compounds, making it indispensable for extraction, synthesis, and cleaning processes. With a boiling point of 116°C and a flash point of 14°C, MIBK offers a balanced volatility profile, ensuring efficient evaporation without excessive flammability risks. Its low water solubility (1.9 g/100 mL at 20°C) enhances its utility in non-aqueous systems, while its miscibility with most organic solvents expands its compatibility in complex formulations. The USP grade designation guarantees stringent purity standards, minimizing impurities that could interfere with sensitive reactions or analyses. MIBK’s moderate polarity (dielectric constant of 13.11) positions it as an ideal intermediate between non-polar hydrocarbons and polar solvents like alcohols, enabling selective solubility in multi-component systems. Its stability under normal laboratory conditions, combined with a density of 0.802 g/mL at 20°C, facilitates precise volumetric measurements and consistent experimental reproducibility. The solvent’s refractive index of 1.396 at 20°C serves as a reliable quality control parameter for verifying purity in critical applications.
FAQs
1. What is the typical shelf life of Methyl Isobutyl Ketone (MIBK) USP when stored properly?
When stored in a tightly sealed container away from heat, sparks, and direct sunlight, MIBK USP maintains its specified purity for at least 24 months from the date of manufacture. The container should be kept in a cool, well-ventilated area with temperatures not exceeding 30°C to prevent degradation or evaporation.
2. Can MIBK USP be used as a direct substitute for acetone in laboratory procedures?
While both are ketones, MIBK and acetone differ significantly in their solvency profiles and evaporation rates. MIBK has a higher boiling point (116°C vs 56°C for acetone) and lower polarity, making it less aggressive toward certain polymers but more selective in extraction applications. Substitution requires evaluating the specific solubility requirements and volatility needs of your procedure.
3. What safety precautions should be taken when handling MIBK in a laboratory setting?
MIBK is classified as a flammable liquid with a flash point of 14°C, requiring handling in a fume hood or well-ventilated area. Wear chemical-resistant gloves (nitrile or neoprene), safety goggles, and a lab coat to prevent skin and eye contact. Avoid inhalation of vapors, as prolonged exposure may cause dizziness or respiratory irritation. Keep away from ignition sources and store in approved flammable liquid cabinets.
4. How does the USP grade of MIBK differ from technical or industrial grades?
USP-grade MIBK undergoes rigorous purification processes to meet United States Pharmacopeia standards, ensuring minimal impurities (typically <0.1% total impurities) and consistent performance in sensitive applications. Technical grades may contain higher levels of contaminants like water, alcohols, or other ketones, which could interfere with analytical results or reaction yields in precision work.
5. What analytical techniques are commonly used to verify the purity of MIBK USP?
Gas chromatography (GC) with flame ionization detection is the standard method for quantifying MIBK purity and identifying trace impurities. Refractive index measurement (1.396 at 20°C) serves as a quick quality check, while Karl Fischer titration can determine water content. For comprehensive analysis, GC-mass spectrometry (GC-MS) provides detailed impurity profiling, particularly for volatile organic compounds that might co-elute in simpler GC methods.
