Description
Specifications Table
Product Name – Methylmagnesium bromide, 1M solution in CPME, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution in cyclopentyl methyl ether)
Grade – Reagent grade
Application – Grignard reactions, carbon-carbon bond formation
Product Overview
Methylmagnesium bromide, 1M solution in CPME (cyclopentyl methyl ether), is a highly reactive Grignard reagent essential for organic synthesis applications. This moisture-sensitive solution is stabilized in CPME, a safer and more environmentally friendly alternative to traditional ethers like THF or diethyl ether. The 1M concentration ensures optimal reactivity for carbon-carbon bond formation, alkylation, and nucleophilic addition reactions. Packaged under nitrogen in AcroSeal® bottles, this reagent maintains purity and prevents degradation from atmospheric exposure. The reagent grade quality guarantees consistent performance in laboratory settings, with minimal byproduct formation. CPME’s higher boiling point (106°C) compared to THF enhances stability during prolonged reactions, while its lower peroxide formation risk improves handling safety. Ideal for researchers requiring reliable organomagnesium compounds, this solution eliminates the need for in-house preparation, reducing contamination risks. Store under inert gas at 2–8°C for long-term stability.
FAQs
1. What is the shelf life of Methylmagnesium bromide 1M in CPME?
When stored unopened at 2–8°C under nitrogen, the solution retains full potency for 12–18 months. Opened bottles should be used within 3 months.
2. Can this reagent replace THF-based Grignard solutions?
Yes, CPME offers comparable solubility for most substrates with improved thermal stability and reduced peroxide formation compared to THF.
3. What precautions are needed for handling this solution?
Use in a fume hood with dry nitrogen atmosphere. Avoid moisture contact—reagent reacts violently with water, releasing flammable methane gas.
4. Is this compatible with glass syringes for transfer?
Yes, but pre-dry syringes and needles with inert gas. PTFE or stainless-steel needles are recommended to prevent corrosion.
5. How does AcroSeal® packaging improve stability?
The bottle’s septum cap allows needle access without exposing the contents to air, minimizing oxidation and moisture absorption during repeated use.
