Description
Specifications Table
Product Name – Lithium diisopropylamide, 2M solution in THF/heptane/ethylbenzene, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution in mixed solvents)
Grade – Reagent grade
Application – Deprotonation, enolate formation, base-catalyzed reactions
Product Overview
Lithium diisopropylamide (LDA), supplied as a 2M solution in a mixture of tetrahydrofuran (THF), heptane, and ethylbenzene, is a powerful, non-nucleophilic base widely used in organic synthesis for selective deprotonation and enolate formation. The AcroSeal® packaging provides an airtight barrier, protecting the reagent from moisture and carbon dioxide, which can neutralize its basicity and reduce effectiveness. This solution is particularly valued for its ability to generate kinetic enolates, making it ideal for regioselective reactions in carbonyl chemistry. The mixed solvent system enhances solubility and stability, while the sealed format ensures long-term storage without degradation. Unlike solid LDA, this pre-dissolved form eliminates handling risks associated with pyrophoric powders, improving laboratory safety. The 2M concentration offers a practical balance between reactivity and ease of dosing, ensuring consistent performance in experimental protocols. Whether used in small-scale research or larger synthetic applications, this solution delivers reliable results with minimal impurities, reducing the likelihood of side reactions and improving yield.
FAQs
1. Can this LDA solution be used for thermodynamic enolate formation?
While LDA typically favors kinetic enolates, prolonged reaction times or elevated temperatures may shift the equilibrium toward thermodynamic products.
2. What precautions should be taken during storage?
Store under inert gas (argon/nitrogen) at 2–8°C, away from moisture and heat sources. Keep the AcroSeal® cap tightly sealed.
3. Is this solution compatible with plastic containers?
No, the solvent mixture can dissolve many plastics. Use only glass or PTFE-lined containers for storage and handling.
4. How does the solvent mixture affect reactivity?
The THF enhances solubility and reactivity, while heptane and ethylbenzene improve stability and reduce the risk of side reactions.
5. What is the typical reaction time for deprotonation?
Most deprotonations occur within minutes at -78°C to room temperature, depending on the substrate and conditions.
