Description
Specifications Table
Product Name – Methylmagnesium bromide, 3.2M solution in 2-MeTHF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution)
Grade – AcroSeal® (high-purity, air/moisture-sensitive)
Application – Grignard reagent, organometallic synthesis, carbon-carbon bond formation
Product Overview
Methylmagnesium bromide, 3.2M solution in 2-MeTHF (2-Methyltetrahydrofuran), is a highly reactive Grignard reagent supplied under the AcroSeal® brand, ensuring superior purity and minimal exposure to air or moisture. This organomagnesium compound is widely recognized for its efficiency in carbon-carbon bond formation, making it indispensable in organic synthesis. The 2-MeTHF solvent enhances solubility and reactivity compared to traditional ethers, offering improved performance in low-temperature reactions. The solution is stabilized to prevent decomposition, maintaining consistent molar concentration for reproducible results. Its air- and moisture-sensitive nature necessitates handling under inert conditions, typically in a glove box or with Schlenk techniques. The AcroSeal® packaging guarantees integrity during storage and transport, minimizing contamination risks. This reagent is particularly valued for its ability to participate in nucleophilic addition, substitution, and conjugate addition reactions, serving as a versatile building block in complex molecular constructions. Proper storage at controlled temperatures and protection from light further extends its shelf life and reactivity.
FAQs
1. What precautions should be taken while handling Methylmagnesium bromide solution?
Always handle under an inert atmosphere (argon/nitrogen) using dry syringes or cannulas. Avoid exposure to air, moisture, or heat sources, as it can react violently. Use flame-resistant labware and wear appropriate PPE, including gloves and goggles.
2. Is this reagent compatible with glassware, or should special materials be used?
The solution is compatible with standard borosilicate glassware, but ensure it is thoroughly dried and free of residual moisture. Avoid plastic containers or rubber septa, as they may react with the Grignard reagent.
3. Can this be substituted with Methylmagnesium chloride for similar reactions?
While both are Grignard reagents, bromide variants often exhibit higher reactivity in certain transformations, such as with sterically hindered substrates. However, chloride may be preferable for specific selectivity requirements. Always verify compatibility with your reaction mechanism.
4. How should leftover solution be disposed of after use?
Neutralize excess reagent cautiously with a slow addition of isopropanol or a saturated ammonium chloride solution in a well-ventilated fume hood. Follow institutional hazardous waste disposal protocols for the quenched mixture.
5. What is the typical shelf life of unopened Methylmagnesium bromide in 2-MeTHF?
When stored unopened at 2–8°C in its original AcroSeal® packaging, the solution retains its specified concentration for up to 12 months. Avoid prolonged storage at room temperature, as it may accelerate solvent evaporation or decomposition.
