Description
Specifications Table
Product Name – N-Ethyl-N-Methylcarbamoyl chloride
Quantity/Pack Size – 25 g
Form – Solid (Powder/Crystals)
Grade – Laboratory Grade
Application – Organic synthesis, carbamate derivatives, pharmaceutical intermediates
Product Overview
N-Ethyl-N-Methylcarbamoyl Chloride is a highly reactive carbamoyl chloride derivative widely used in organic synthesis for the preparation of carbamate esters, ureas, and other nitrogen-containing compounds. This laboratory-grade reagent exhibits excellent purity and stability, ensuring reliable results in sensitive reactions. Its molecular structure features an ethyl-methyl-substituted carbamoyl group bonded to a chlorine atom, enabling nucleophilic substitution under mild conditions. The compound is particularly valued for its selectivity in forming carbamate linkages, making it indispensable in peptide synthesis, agrochemical development, and pharmaceutical intermediate production. With a balanced reactivity profile, it minimizes side reactions while maintaining high conversion efficiency. The solid form (typically fine powder or crystals) allows for easy handling and precise weighing in laboratory settings. Proper storage under cool, dry conditions preserves its reactivity over extended periods. Compatibility with common organic solvents further enhances its versatility in multi-step synthetic protocols.
FAQs
1. What is the typical shelf life of N-Ethyl-N-Methylcarbamoyl Chloride when stored properly?
When stored in a tightly sealed container under refrigeration (2-8°C) and protected from moisture, this reagent maintains its specified purity for up to 24 months from the date of manufacture. Always check the certificate of analysis for batch-specific stability data.
2. Can this compound be used directly in aqueous reaction systems?
The reagent hydrolyzes rapidly in water, forming the corresponding carbamic acid derivative. For aqueous systems, pre-dissolve in an organic co-solvent like THF or acetonitrile before gradual addition to the aqueous phase to control the reaction rate.
3. What are the recommended alternatives if this specific carbamoyl chloride is unavailable?
Depending on your synthesis requirements, consider isopropyl chloroformate for similar reactivity with altered steric properties, or dimethylcarbamoyl chloride for simpler methyl-substituted derivatives. Reaction conditions may need optimization when switching reagents.
4. How should I dispose of unused or expired N-Ethyl-N-Methylcarbamoyl Chloride?
Neutralize small quantities by slow addition to a 10% sodium hydroxide solution in a well-ventilated fume hood, followed by dilution with water before disposal. For larger amounts, consult local hazardous waste regulations or contact a licensed chemical disposal service.
5. What safety precautions are essential when handling this compound?
Always wear nitrile gloves, safety goggles, and work in a fume hood due to its corrosive and lachrymatory properties. Avoid inhalation of dust and skin contact, as it may cause severe irritation. Keep a spill kit with sodium bicarbonate readily available for accidental releases.
