Description
Specifications Table
Product Name – N,N-Dimethylformamide (for peptide synthesis)
Quantity/Pack Size – 2.5 L
Form – Liquid
Grade – Peptide Synthesis Grade
Application – Peptide synthesis, organic synthesis, solvent applications
Product Overview
N,N-Dimethylformamide (DMF) is a high-purity, polar aprotic solvent specifically formulated for peptide synthesis and advanced organic chemistry applications. Known for its exceptional solvating power, DMF effectively dissolves a wide range of polar and non-polar compounds, making it indispensable in laboratory settings where precision and consistency are critical. This peptide synthesis-grade DMF undergoes rigorous purification processes to eliminate impurities, ensuring minimal interference with sensitive reactions. Its low volatility and high boiling point contribute to stable reaction conditions, while its compatibility with various reagents and catalysts enhances its versatility. The solvent’s ability to facilitate amide bond formation without racemization makes it particularly valuable in solid-phase peptide synthesis (SPPS) and solution-phase methodologies. Additionally, its miscibility with water and organic solvents allows for seamless integration into multi-step synthesis protocols. Designed to meet stringent laboratory standards, this DMF variant adheres to strict quality control measures, guaranteeing reproducibility in experimental outcomes. Whether used as a reaction medium, co-solvent, or extraction agent, its chemical stability and inertness under typical lab conditions ensure reliable performance across diverse applications.
FAQs
1. What is the primary advantage of using this DMF for peptide synthesis?
This DMF is optimized for peptide synthesis due to its high purity, which minimizes side reactions and ensures efficient amide bond formation without racemization.
2. Can this DMF be used as a solvent for other organic reactions?
Yes, its broad solubility profile makes it suitable for various organic synthesis applications beyond peptide chemistry, including nucleophilic substitutions and transition-metal catalysis.
3. How should this DMF be stored to maintain its quality?
Store in a tightly sealed container under inert gas (e.g., nitrogen) in a cool, dry place, away from moisture and direct sunlight to prevent degradation.
4. Is this DMF compatible with common coupling reagents like DCC or HOBt?
Yes, it is fully compatible with standard peptide coupling reagents, including carbodiimides (DCC, EDC) and additives like HOBt or HOAt.
5. Are there any safety precautions to consider when handling this DMF?
Handle in a fume hood with proper PPE (gloves, goggles) due to its potential skin irritation and moderate toxicity upon inhalation or ingestion.
