Description
Specifications Table
Product Name – p-Tolylmagnesium bromide, approx. 0.5M solution in diethyl ether, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution in diethyl ether)
Grade – Laboratory reagent grade
Application – Grignard reagent for organic synthesis, carbon-carbon bond formation
Product Overview
p-Tolylmagnesium bromide is a highly reactive Grignard reagent supplied as a 0.5M solution in anhydrous diethyl ether, packaged under the AcroSeal® system to ensure maximum stability and purity. This organomagnesium compound is widely utilized in synthetic chemistry for introducing p-tolyl (4-methylphenyl) groups into organic molecules through nucleophilic addition or substitution reactions. The solution is stabilized in diethyl ether, which serves as both a solvent and a stabilizing medium, preventing premature decomposition. The AcroSeal® packaging technology provides an airtight, moisture-resistant seal, critical for maintaining the reagent’s reactivity over extended storage periods. This product is particularly valued for its consistency in yield and selectivity, making it a reliable choice for laboratory-scale syntheses. The reagent’s concentration is optimized at 0.5M to balance reactivity with ease of handling, while the ether solvent ensures compatibility with a broad range of reaction conditions. Proper storage under inert atmosphere and away from moisture is essential to preserve its chemical integrity.
FAQs
1. What is the typical shelf life of p-Tolylmagnesium bromide solution when stored properly?
When stored unopened in its original AcroSeal® packaging at temperatures between 2-8°C and protected from moisture, the solution retains its specified concentration and reactivity for up to 12 months from the date of manufacture. Always check the bottle label for the exact expiration date.
2. Can this Grignard reagent be used directly in reactions without further purification?
The solution is provided as a standardized 0.5M reagent and is generally suitable for direct use in most synthetic applications. However, if your protocol requires anhydrous conditions or ultra-high purity, you may need to titrate the solution prior to use to confirm the exact molarity, as minor variations can occur during storage.
3. What precautions should be taken when handling diethyl ether-based Grignard solutions?
Diethyl ether is highly flammable and forms explosive peroxides upon exposure to air and light. Always handle the solution in a well-ventilated fume hood, away from ignition sources. Use peroxide-free ether if long-term storage is required, and never distill the solvent to dryness due to peroxide explosion risks.
4. Is this reagent compatible with glassware, or are special materials required?
The solution can be safely stored and handled in standard borosilicate glassware, which is resistant to ether and organomagnesium compounds. Avoid using plastic containers or pipettes, as ether can dissolve or degrade many plastics. Ensure all glassware is thoroughly dried and inert (e.g., flame-dried or purged with nitrogen) before use.
5. How does the AcroSeal® packaging improve the stability of this Grignard reagent?
The AcroSeal® system uses a patented septum and valve design that minimizes exposure to moisture and oxygen during storage and dispensing. This reduces the risk of hydrolysis or oxidation, which are common degradation pathways for Grignard reagents. The seal also allows for multiple withdrawals without significant loss of reagent quality.
