Description
Specifications Table
Product Name – Potassium tri-sec-butylborohydride, 1M solution in tetrahydrofuran, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – AcroSeal® (high-purity, air/moisture-sensitive)
Application – Selective reducing agent in organic synthesis
Product Overview
Potassium tri-sec-butylborohydride (K-Selectride® equivalent) is a 1M solution in anhydrous tetrahydrofuran (THF), packaged under the AcroSeal® system to ensure maximum stability and purity. This organoborohydride reagent is renowned for its exceptional selectivity in reducing ketones, aldehydes, and other carbonyl compounds while minimizing over-reduction or side reactions. The THF solvent provides optimal solubility and reactivity, making it ideal for sensitive synthetic transformations. The AcroSeal® packaging features a septum-sealed bottle with a PTFE-lined cap, preventing air and moisture contamination that could degrade the reagent. Each batch undergoes rigorous quality control to guarantee consistent performance, with residual water content maintained below 50 ppm. The reagent’s sterically hindered structure enables chemoselective reductions even in the presence of other reducible functional groups. Store under inert atmosphere (argon/nitrogen) at 2-8°C for long-term stability, though short-term exposure to room temperature is acceptable for immediate use.
FAQs
1. What is the typical shelf life of this reagent when stored properly?
When stored unopened under inert gas at 2-8°C, the reagent maintains full potency for 12-18 months from the date of manufacture. Always verify the expiration date on the label.
2. Can this solution be used directly without further drying?
The AcroSeal® packaging ensures minimal moisture content (<50 ppm), so the solution can typically be used as received. For ultra-sensitive applications, further drying with molecular sieves may be advisable.
3. What safety precautions are essential when handling this reagent?
Always work in a well-ventilated fume hood, wear nitrile gloves, and use air-free techniques. The reagent is pyrophoric in air and reacts violently with water, releasing flammable hydrogen gas.
4. Is this compatible with standard glass syringes for transfer?
Yes, but use PTFE-tipped or all-plastic syringes to prevent contamination. Rinse syringes thoroughly with dry THF before and after use to avoid cross-contamination.
5. How does this compare to lithium tri-sec-butylborohydride (L-Selectride)?
The potassium salt offers similar selectivity but with slightly higher basicity, which can influence reaction rates. Both are effective for 1,2-reductions, though the potassium variant may provide better solubility in ethereal solvents.
