Specifications Table

Product Name – Propanephosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid
Grade – AcroSeal® (High Purity)
Application – Organic synthesis, peptide coupling, chemical modifications

Product Overview

Propanephosphonic acid cyclic anhydride, supplied as a 50 wt.% solution in ethyl acetate under the AcroSeal® grade, is a highly reactive organophosphorus compound used in advanced chemical synthesis. This solution offers exceptional purity and stability, making it suitable for demanding applications such as peptide coupling, phosphonate synthesis, and modification of organic molecules. The ethyl acetate solvent ensures compatibility with a wide range of reaction conditions, while the AcroSeal® packaging guarantees minimal exposure to moisture and contaminants, preserving reagent integrity. Its cyclic anhydride structure enables efficient phosphorylation reactions, reducing side products and improving yield. Researchers and chemists rely on this reagent for its consistent performance in complex synthetic pathways, particularly in the preparation of biologically active compounds and specialty chemicals. The solution’s controlled concentration ensures reproducibility in experimental protocols, making it a preferred choice for high-precision laboratory work.

FAQs

1. What is the shelf life of propanephosphonic acid cyclic anhydride solution?

When stored unopened in its original AcroSeal® packaging at room temperature, the solution remains stable for at least 12 months. Exposure to moisture or air may reduce its effectiveness over time.

2. Is this solution compatible with aqueous reaction systems?

The ethyl acetate solvent is immiscible with water, so the solution is best suited for anhydrous or organic solvent-based reactions. For aqueous systems, consider alternative phosphonating agents or pre-dissolution in a co-solvent.

3. Can this reagent be used as a direct replacement for T3P® in synthesis?

Yes, propanephosphonic acid cyclic anhydride functions similarly to T3P® (propanephosphonic acid anhydride) in most applications, including amide bond formation and esterification, though optimization of reaction conditions may be required.

4. What precautions should be taken during handling?

This solution is moisture-sensitive and corrosive. Use in a fume hood with proper PPE (gloves, goggles, lab coat) and avoid inhalation or skin contact. Store under inert gas if transferring to secondary containers.

5. Are there lower-concentration alternatives available for less reactive applications?

While this product is standardized at 50 wt.%, dilution with dry ethyl acetate can adjust concentration for milder reactions. For pre-diluted options, explore specialty suppliers or custom synthesis services.