Description
Specifications Table
Product Name – Sodium cyanoborohydride, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – Reagent grade
Application – Reductive amination, bioconjugation
Product Overview
Sodium cyanoborohydride (NaBH₃CN) in a 1M tetrahydrofuran (THF) solution is a highly selective reducing agent critical for reductive amination and bioconjugation reactions. The AcroSeal® packaging ensures long-term stability by minimizing moisture exposure, which is essential for maintaining reagent efficacy. This solution offers controlled reactivity, making it suitable for delicate biochemical applications where mild reduction conditions are required. The THF solvent enhances solubility and compatibility with organic substrates, ensuring consistent performance in complex synthesis workflows. Unlike traditional borohydrides, sodium cyanoborohydride selectively reduces imines and aldehydes without affecting ketones or other functional groups, providing precise reaction control. The reagent is widely used in peptide synthesis, carbohydrate chemistry, and pharmaceutical intermediates due to its reliability and reproducibility. Proper handling and storage are crucial to prevent degradation, as the compound is sensitive to moisture and air. The AcroSeal® technology further extends shelf life, reducing waste and ensuring cost-efficiency for frequent lab use.
FAQs
1. What is the shelf life of sodium cyanoborohydride in THF solution?
The shelf life is typically 12 months when stored unopened in its original AcroSeal® packaging at room temperature, protected from light and moisture.
2. Can this solution be used for large-scale synthesis?
Yes, the 800ML pack size is designed for scalable applications, though reaction conditions may need optimization for bulk use.
3. Is this reagent compatible with aqueous buffers?
No, sodium cyanoborohydride decomposes in water. Use anhydrous solvents like THF or methanol for optimal results.
4. What safety precautions are necessary when handling this solution?
Wear nitrile gloves, safety goggles, and work in a fume hood due to the toxic and flammable nature of THF and cyanoborohydride.
5. Are there alternatives for moisture-sensitive applications?
Sodium triacetoxyborohydride is a less moisture-sensitive alternative, though it may require different reaction conditions.
