Description
Specifications Table
| Product Name | tert-Butylchlorodimethylsilane, 1.0M solution in dichloromethane, AcroSeal® |
|---|---|
| Pack Size | 100ML |
| Form | Liquid |
| Grade | Research Grade |
| Application | Silylation reactions, organic synthesis |
Product Description
tert-Butylchlorodimethylsilane (TBDMSCl) is a versatile silylating agent widely used in organic chemistry to protect hydroxyl groups during synthesis. This 1.0M solution in dichloromethane offers convenience and stability, making it ideal for research labs and academic settings. The AcroSeal® packaging ensures minimal exposure to moisture, preserving the reagent’s reactivity.
Whether you’re working on peptide synthesis, nucleic acid modifications, or complex organic molecules, this solution provides consistent performance. Researchers often choose this product for its reliability in protecting alcohols, phenols, and carboxylic acids. The dichloromethane solvent enhances solubility, simplifying reaction setups.
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Key Applications
This solution is particularly useful in:
- Protecting hydroxyl groups in multi-step syntheses
- Preparing silyl ethers for further functionalization
- Modifying biomolecules for stability studies
Safety and Handling
Risk Note: tert-Butylchlorodimethylsilane is corrosive and moisture-sensitive. Always handle in a fume hood with proper PPE. Store under inert atmosphere.
FAQs
What is tert-butylchlorodimethylsilane used for?
It’s primarily used as a protecting group for alcohols in organic synthesis, preventing unwanted side reactions during complex molecule construction.
How should I store this solution?
Store at room temperature in a tightly sealed container under nitrogen or argon to prevent moisture contamination.
Can I use this for peptide synthesis?
Yes, it’s commonly used to protect serine and threonine residues during peptide chain assembly.
What’s the shelf life of this product?
When stored properly, the solution maintains stability for 12-24 months. Check the expiration date on the label.
Is this solution compatible with all organic solvents?
While dichloromethane is the standard solvent, it can be used with other anhydrous solvents like THF or toluene for specific applications.
