Description
Specifications Table
| Product Name | Tert-Butyldimethylchlorosilane For Synth | 8.18642.0100 | Merck |
|---|---|
| Quantity/Pack Size | 100 GM |
| Form | Liquid |
| Grade | For Synthesis |
| Application | Protecting agent for hydroxyl groups in organic synthesis |
Product Description
Tert-Butyldimethylchlorosilane, often abbreviated as TBSCl, is a versatile silylating agent widely used in organic synthesis for protecting hydroxyl groups. This high-purity reagent from Merck ensures reliable performance in sensitive reactions, making it a staple in research labs and academic settings. Whether you’re working on peptide synthesis, carbohydrate chemistry, or complex natural product derivatization, this compound provides excellent selectivity and stability under a variety of conditions.
At eqipped, we understand the importance of sourcing lab chemicals that meet stringent quality standards. This 100g pack is ideal for both small-scale experiments and larger synthetic projects, offering the perfect balance between quantity and shelf life. The synthesis-grade purity guarantees minimal impurities, reducing the risk of side reactions and ensuring cleaner yields.
Researchers and students alike will appreciate the ease of use and consistency of this product. Unlike other protecting groups, the tert-butyldimethylsilyl (TBS) group is stable under mildly basic conditions but can be selectively removed with fluoride sources like TBAF, making it a preferred choice for multi-step syntheses. Its compatibility with a wide range of solvents further enhances its utility in diverse experimental setups.
Need tert butyldimethylchlorosilane for your next experiment? Order now and get authentic Merck quality delivered to your lab.
When working with this reagent, proper handling is crucial. Always use it in a fume hood and dispose of waste according to local regulations. For best results, store the bottle tightly sealed and avoid exposure to moisture, which can lead to premature hydrolysis. If you’re new to using silyl protecting groups, consider consulting standard organic chemistry protocols or lab manuals for optimized reaction conditions.
The applications of tert butyldimethylchlorosilane extend beyond traditional organic synthesis. It’s also employed in materials science for surface modifications and in biochemistry for protecting sensitive functional groups during probe synthesis. This versatility makes it a valuable addition to any chemistry lab’s reagent inventory.
For institutions and research groups looking to buy tert butyldimethylchlorosilane in bulk, eqipped offers competitive pricing and reliable supply chains. Our platform connects you directly with genuine Merck products, eliminating concerns about counterfeit or substandard chemicals that could compromise your research.
FAQs
What is tert butyldimethylchlorosilane used for?
It’s primarily used as a protecting agent for hydroxyl groups in organic synthesis, preventing unwanted reactions during multi-step processes.
How should I store tert butyldimethylchlorosilane?
Store in a cool, dry place with the bottle tightly sealed. Keep away from moisture and incompatible substances like strong acids or oxidizing agents.
What safety precautions should I take when handling this chemical?
Always work in a fume hood, wear appropriate PPE (gloves, goggles, lab coat), and avoid inhalation or skin contact. Follow standard lab safety protocols.
Can I use this for peptide synthesis?
Yes, tert butyldimethylchlorosilane is commonly used in peptide synthesis to protect serine, threonine, and tyrosine residues.
How do I remove the TBS protecting group?
The TBS group can be selectively removed using fluoride sources like tetrabutylammonium fluoride (TBAF) or acidic conditions depending on your specific reaction requirements.
