Description
Specifications Table
Product Name – tert-Butylmagnesium chloride, 1.7M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – AcroSeal® (high-purity, air/moisture-sensitive)
Application – Organic synthesis, Grignard reactions, carbon-carbon bond formation
Product Overview
tert-Butylmagnesium chloride (1.7M in THF) is a highly reactive Grignard reagent supplied in an AcroSeal® packaging system to ensure maximum stability and purity during storage and handling. This organomagnesium compound is widely recognized for its role in facilitating carbon-carbon bond formation, enabling efficient synthesis of complex organic molecules. The THF (tetrahydrofuran) solvent enhances solubility and reactivity, making it ideal for demanding laboratory applications where precision and consistency are critical. The 1.7M concentration provides an optimal balance between reactivity and ease of use, reducing the need for additional dilution while maintaining high conversion rates in synthetic protocols. The AcroSeal® technology minimizes exposure to air and moisture, preserving the reagent’s integrity and extending shelf life. This product is particularly valued for its ability to participate in nucleophilic addition reactions, halogen-magnesium exchange, and conjugate addition processes. Proper handling under inert conditions is essential to maintain its efficacy, as the reagent is highly sensitive to atmospheric moisture and oxygen.
FAQs
1. What precautions should be taken while handling tert-Butylmagnesium chloride?
Always handle under an inert atmosphere (nitrogen or argon) using dry, air-free techniques. Avoid exposure to moisture or air, as it reacts violently with water. Use compatible glassware and ensure proper grounding to prevent static discharge.
2. Is this reagent compatible with standard Schlenk line techniques?
Yes, tert-Butylmagnesium chloride in THF is fully compatible with Schlenk line or glove box techniques. Ensure all glassware is thoroughly dried and purged with inert gas before use to prevent decomposition.
3. What are the storage requirements for this product?
Store the sealed container in a cool, dry place under inert gas, away from ignition sources. The AcroSeal® packaging helps maintain stability, but prolonged storage should be avoided to prevent solvent evaporation or reagent degradation.
4. Can this reagent be used as a substitute for other Grignard reagents?
While it shares similar reactivity, tert-Butylmagnesium chloride offers steric bulk that may influence reaction selectivity. Test compatibility with your specific synthesis, as the tert-butyl group can impact yields or side reactions compared to linear alkyl Grignard reagents.
5. How does the THF solvent affect the reagent’s performance?
THF enhances solubility and reactivity due to its coordinating properties, but it can also participate in side reactions under extreme conditions. For sensitive applications, consider solvent-free alternatives or lower temperatures to minimize solvent interference.
