Description
Specifications Table
Product Name – Tetrabutylammonium fluoride, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – Reagent grade
Application – Silyl ether deprotection, nucleophilic fluorination, organic synthesis
Product Overview
Tetrabutylammonium fluoride (TBAF) as a 1M solution in anhydrous tetrahydrofuran (THF) is a highly reactive fluoride source widely employed in organic synthesis for its exceptional desilylation efficiency. The AcroSeal® packaging ensures minimal moisture exposure, preserving the reagent’s potency for demanding applications like cleaving silyl ethers or generating nucleophilic fluoride ions under anhydrous conditions. This reagent-grade solution is stabilized with THF, a polar aprotic solvent that enhances solubility while maintaining compatibility with moisture-sensitive reactions. The 1M concentration provides an optimal balance between reactivity and ease of dosing, eliminating the need for solid TBAF handling. Its low water content (<50 ppm) and sealed delivery system prevent hydrolysis, ensuring consistent performance in fluorination protocols. The solution’s clarity and absence of insoluble particulates guarantee reliable stoichiometry in high-value syntheses. For researchers requiring precise fluoride delivery without solid handling hazards, this pre-dissolved TBAF formulation offers operational convenience alongside analytical-grade purity.
FAQs
1. What is the typical moisture content of this TBAF solution?
The anhydrous THF solvent and AcroSeal® packaging maintain water levels below 50 ppm, verified via Karl Fischer titration.
2. Can this solution be used directly for TMS ether deprotection?
Yes, the 1M concentration is ideal for cleaving trimethylsilyl (TMS) ethers without requiring additional solvent or concentration adjustments.
3. How does the AcroSeal® packaging differ from standard bottles?
AcroSeal® features a PTFE-lined septum and airtight valve that prevents atmospheric moisture ingress during repeated withdrawals, unlike traditional screw-cap bottles.
4. Is this solution compatible with glass syringes for transfer?
The THF-based solution is fully compatible with glass syringes, though PTFE-tipped needles are recommended to prevent corrosion from trace fluoride ions.
5. What’s the shelf life when stored unopened at room temperature?
When stored in the original AcroSeal® container at 15–25°C, the solution retains its specified purity for 24 months from the date of manufacture.
