Specifications Table

Product Name – (Trimethylsilyl)diazomethane, 2M solution in hexanes
Quantity/Pack Size – 5ML
Form – Liquid (solution in hexanes)
Grade – Laboratory/Reagent Grade
Application – Methylation reagent, esterification, organic synthesis

Product Overview

(Trimethylsilyl)diazomethane (TMS-diazomethane), supplied as a 2M solution in hexanes, is a highly reactive and versatile reagent widely used in organic synthesis for selective methylation and esterification reactions. This moisture-sensitive compound offers a safer alternative to traditional diazomethane, providing controlled reactivity while minimizing hazards. The hexane solvent ensures stability during storage and handling, though it requires inert gas protection to prevent decomposition. Its high purity and consistent concentration make it ideal for demanding laboratory applications where precision is critical. The reagent’s ability to methylate carboxylic acids, phenols, and alcohols without affecting other functional groups enhances its utility in complex synthetic routes. Due to its sensitivity to light and heat, proper storage in a cool, dark environment is essential to maintain integrity. Equipped’s (Trimethylsilyl)diazomethane is rigorously tested for purity and concentration, ensuring reliable performance in research and development settings.

FAQs

1. What precautions should be taken while handling (Trimethylsilyl)diazomethane?

Always handle under an inert atmosphere (argon/nitrogen) in a fume hood. Avoid exposure to moisture, heat, or open flames, as it can decompose violently. Use appropriate PPE, including gloves and goggles.

2. Is this reagent compatible with polar solvents like methanol or water?

No, (Trimethylsilyl)diazomethane reacts violently with protic solvents (e.g., methanol, water) and alcohols. Use only anhydrous, aprotic solvents like THF or dichloromethane for dilution if necessary.

3. Can this be used as a substitute for diazomethane in all reactions?

While it serves as a safer alternative for most methylation reactions, its reactivity profile differs slightly. Test compatibility with your specific substrate, as some reactions may require adjustments in conditions or stoichiometry.

4. How should unused solution be stored to extend shelf life?

Store the sealed bottle at 2–8°C in a desiccator or under inert gas, protected from light. Avoid repeated freeze-thaw cycles, and use within the recommended expiry period for optimal reactivity.

5. What is the typical lead time for delivery in metro cities like Bangalore or Hyderabad?

Orders are dispatched within 1–2 business days, with delivery to metro cities typically completed in 3–5 days via express courier. Track your shipment for real-time updates.