Specifications Table

Product Name – (Trimethylsilyl)methylmagnesium chloride, 1.3M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (solution in THF)
Grade – Reagent grade, 99% purity
Application – Organosilicon compound synthesis, Grignard reagent for C-Si bond formation

Product Overview

(Trimethylsilyl)methylmagnesium chloride is a highly reactive Grignard reagent supplied as a 1.3M solution in tetrahydrofuran (THF), designed for precise organosilicon synthesis applications. The AcroSeal® packaging ensures airtight protection against moisture and oxygen, preserving the reagent’s stability and reactivity over extended storage periods. This solution maintains a minimum 99% purity, making it suitable for demanding synthetic routes where trace impurities could compromise yields or selectivity. The THF solvent enhances solubility and compatibility with a wide range of organic substrates, facilitating smooth reaction kinetics. Its trimethylsilyl group introduces steric and electronic effects that are critical in silicon-based transformations, including the formation of carbon-silicon bonds. The reagent’s concentration (1.3M) is optimized to balance reactivity with ease of handling, reducing the need for excessive solvent volumes in large-scale preparations. For researchers requiring reproducible results, the AcroSeal® system minimizes exposure to atmospheric contaminants during dispensing, while the amber glass bottle provides additional protection against light-induced degradation. This product is particularly valued in laboratories where moisture-sensitive reactions are routine, offering a reliable alternative to in-house preparations of similar reagents.

FAQs

1. What is the shelf life of (Trimethylsilyl)methylmagnesium chloride in THF when stored under ideal conditions?

The reagent remains stable for up to 12 months from the date of manufacture when stored at 2–8°C in its original, unopened AcroSeal® packaging. Avoid prolonged exposure to temperatures above 25°C, as this may accelerate solvent evaporation or decomposition.

2. Can this reagent be used directly in reactions without further purification?

Yes, the 99% purity and AcroSeal® protection eliminate the need for additional purification steps in most applications. However, if your protocol requires anhydrous conditions, we recommend transferring the solution under inert gas (e.g., nitrogen or argon) to exclude residual moisture.

3. Is this solution compatible with standard glass syringes for dispensing?

The reagent can be dispensed using glass syringes, but we advise using PTFE-tipped or stainless-steel needles to prevent corrosion from the Grignard reagent. Always flush the syringe with dry THF after use to avoid clogging.

4. What alternatives exist if my reaction requires a lower concentration of this Grignard reagent?

You can dilute the 1.3M solution with anhydrous THF to achieve the desired molarity. For example, mixing 1 part reagent with 2 parts THF yields a ~0.43M solution. Ensure all solvents and equipment are dry to prevent side reactions.

5. How should I dispose of unused or expired (Trimethylsilyl)methylmagnesium chloride solution?

Neutralize the reagent by slowly adding it to a cold, dilute aqueous acid (e.g., 1M HCl) in a well-ventilated fume hood. Once quenched, dispose of the resulting mixture according to local regulations for organic halogenated waste. Never discard untreated Grignard reagents in regular waste streams.