Description
Specifications Table
Product Name – Trimethyltin chloride, 1M (25 wt.%) solution in hexanes, AcroSeal®
Quantity/Pack Size – 100ML
Form – Liquid solution
Grade – Laboratory/Reagent
Application – Organometallic synthesis, catalyst preparation, air-sensitive chemistry
Product Overview
Trimethyltin chloride, supplied as a 1M (25 wt.%) solution in hexanes under the AcroSeal® brand, is a highly specialized organotin reagent designed for demanding laboratory applications where moisture and oxygen sensitivity are critical concerns. The hexanes solvent ensures optimal solubility and reactivity, while the AcroSeal® packaging guarantees long-term stability by minimizing exposure to atmospheric contaminants. This solution is particularly valued in organometallic chemistry for its role in transmetalation reactions, where the trimethyltin moiety acts as a versatile intermediate for synthesizing complex tin-containing compounds. The 25 wt.% concentration balances reactivity with ease of handling, reducing the need for dilution while maintaining precise stoichiometric control. As a laboratory-grade reagent, it undergoes rigorous purity testing to eliminate trace metal impurities that could interfere with sensitive reactions. The clear, colorless solution is compatible with standard Schlenk techniques and glove-box environments, making it ideal for air-free synthesis protocols. Its low volatility in hexanes further enhances safety during storage and manipulation, though standard organotin handling precautions remain essential due to its toxicological profile.
FAQs
1. Can this solution be used directly in Grignard reactions without further purification?
The AcroSeal® packaging ensures minimal contamination, but for highly sensitive Grignard reactions, we recommend verifying moisture content via Karl Fischer titration if your protocol demands absolute anhydrous conditions. The hexanes solvent is typically dry enough for most applications.
2. What is the typical shelf life when stored under nitrogen in the original container?
When kept unopened in its original AcroSeal® bottle under nitrogen at 2-8°C, the solution remains stable for 24 months from the date of manufacture. Once opened, use within 6 months or reprotect with inert gas after each use.
3. Are there any known incompatibilities with PTFE or glass laboratory equipment?
The solution is compatible with borosilicate glass and PTFE-lined components. However, prolonged contact with bare aluminum or copper alloys may lead to decomposition. Always use glass or PTFE-coated magnetic stir bars to avoid metal contamination.
4. How does the 25 wt.% concentration compare to neat trimethyltin chloride in terms of reactivity?
The hexanes-diluted form exhibits slightly reduced exothermic potential compared to neat trimethyltin chloride, making it safer for scale-up reactions while maintaining equivalent molar reactivity. The solvent also facilitates better temperature control during additions.
5. What analytical methods are recommended for verifying the solution’s concentration?
For routine verification, 1H NMR spectroscopy (using the trimethyltin proton signal at ~0.5 ppm) or complexometric titration with EDTA are most practical. For higher precision, ICP-OES analysis for tin content can be performed, though this requires specialized equipment.
