Description
Specifications Table
Product Name – Vinyl bromide, 1M solution in THF, AcroSeal®
Quantity/Pack Size – 100ML, 800ML
Form – Liquid (THF solution)
Grade – AcroSeal® (high-purity, moisture-controlled)
Application – Organic synthesis, halogenation, cross-coupling reactions, polymer chemistry
Product Overview
Vinyl bromide 1M solution in tetrahydrofuran (THF) is a specialized organobromine reagent designed for high-efficiency synthetic applications where precise halogen incorporation is critical. The AcroSeal® packaging ensures exceptional purity by minimizing exposure to atmospheric moisture and oxygen, preserving the reagent’s reactivity and extending shelf life. This solution eliminates the need for in-house dilution, providing a ready-to-use concentration optimized for reproducibility in sensitive reactions. The THF solvent enhances solubility for vinyl bromide while maintaining compatibility with most organic reaction conditions, including palladium-catalyzed couplings and radical initiations. Its sealed format reduces waste from degradation, making it cost-effective for both small-scale experiments and process-scale synthesis. The reagent’s stability in solution allows for consistent performance across batch reactions, with minimal byproduct formation compared to solid vinyl bromide alternatives. Ideal for laboratories requiring reliable brominated vinyl intermediates without the handling hazards of gaseous or neat liquid forms.
FAQs
1. What is the typical shelf life of vinyl bromide 1M in THF under AcroSeal® packaging?
The AcroSeal® packaging extends the shelf life to 12–18 months when stored unopened at 2–8°C. Once opened, use within 3 months for optimal reactivity, as THF is hygroscopic and may absorb moisture over time.
2. Can this solution be used directly in Suzuki-Miyaura coupling reactions?
Yes, the 1M concentration is suitable for Suzuki-Miyaura couplings, but the reaction may require additional base or catalyst optimization depending on the substrate. The THF solvent is compatible with most palladium catalyst systems.
3. Are there any known incompatibilities with common laboratory materials?
Avoid contact with strong oxidizing agents, acids, or metals like aluminum and magnesium, which may react violently with THF. Use glass or PTFE-lined containers; avoid rubber stoppers, as THF can degrade certain elastomers.
4. How does the AcroSeal® packaging differ from standard amber bottles?
AcroSeal® uses a multi-layer barrier with an inert gas purge and resealable septum, significantly reducing oxygen/moisture ingress compared to traditional screw-cap bottles. This design maintains reagent integrity during repeated access.
5. What alternative solvents can be used if THF is not suitable for my application?
For THF-sensitive reactions, consider diethyl ether or toluene as alternatives, though solubility and reaction kinetics may vary. Note that vinyl bromide’s stability in these solvents should be verified prior to use.
