Description
Specifications Table
| Product Name | Water With 0.1% Trifluoroacetic Acid for LCMS |
|---|---|
| Pack Size | 1L |
| Form | Liquid |
| Grade | LCMS/HHPLC |
| Application | Mobile phase solvent for LCMS, mass spectrometry, protein analysis |
Product Description
When precision matters in liquid chromatography-mass spectrometry (LCMS), the quality of your mobile phase solvent can make or break your results. This 0.1% trifluoroacetic acid (TFA) water solution is specially formulated for LCMS applications, offering ultra-low background noise and consistent ionization efficiency. Whether you’re analyzing peptides, proteins, or small molecules, this solvent ensures reliable data with minimal signal suppression.
Trifluoroacetic acid is a common ion-pairing agent in reverse-phase LCMS, but its purity and concentration must be tightly controlled. This HPLC-grade solution eliminates the guesswork, providing a ready-to-use solvent that meets strict analytical standards. Researchers and lab technicians trust this formulation for its batch-to-batch consistency, reducing variability in retention times and peak shapes.
For labs running high-throughput analyses, this solvent is a game-changer. Its low UV absorbance and volatile nature prevent residue buildup in your LCMS system, extending column lifespan and reducing maintenance downtime. Plus, the 1L pack size is ideal for frequent users, balancing cost-efficiency with storage convenience.
Upgrade your LCMS workflow today. Buy 0.1% TFA water online and experience the difference in your chromatograms.
Why This Solvent Stands Out
Not all TFA water solutions are created equal. This product is manufactured under stringent quality controls to ensure:
- Ultra-pure water base (18.2 MΩ-cm resistivity) to prevent ionic interference
- Precise 0.1% TFA concentration for reproducible ion-pairing effects
- Filtered through 0.22 µm membranes to remove particulate contaminants
- Low endotoxin levels for biocompatible applications
These features make it the preferred choice for labs working on proteomics, metabolomics, or pharmaceutical analysis where sensitivity and accuracy are non-negotiable.
Common Applications
This solvent is versatile enough for multiple LCMS techniques:
- Peptide mapping in protein characterization studies
- Drug metabolism and pharmacokinetic (DMPK) screening
- Small molecule quantification in complex matrices
- Glycan analysis with mass spectrometry detection
Its compatibility with both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources makes it a staple in modern analytical labs.
Safety and Handling
Risk Note: Trifluoroacetic acid is corrosive and toxic. Handle with nitrile gloves, safety goggles, and in a fume hood. Avoid inhalation or skin contact. Neutralize spills with sodium bicarbonate.
Store at room temperature (15–25°C) in a tightly sealed container. Keep away from oxidizing agents and bases. For disposal, follow local regulations for hazardous chemical waste.
FAQs
What is the shelf life of this 0.1% TFA water solution?
The product remains stable for 24 months from the manufacturing date when stored unopened under recommended conditions. Once opened, use within 6 months for optimal performance.
Can I use this solvent for UPLC systems?
Yes, this LCMS-grade solvent is compatible with UPLC systems. Its low particulate count and high purity prevent column clogging, even at high pressures.
How does TFA improve LCMS sensitivity?
TFA acts as an ion-pairing agent, enhancing the protonation of analytes like peptides. This improves ionization efficiency in ESI sources, leading to stronger MS signals and better detection limits.
Is this solution suitable for LC-MS/MS?
Absolutely. The ultra-pure formulation minimizes background noise, which is critical for tandem mass spectrometry where multiple reaction monitoring (MRM) requires high signal-to-noise ratios.
Does eqipped offer bulk discounts for this product?
Yes, eqipped provides competitive pricing for bulk orders. Contact our sales team for customized quotes based on your lab’s volume requirements.
